Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation

Luís F. Ribeiro; Tatiana Catarino; Mário Carvalho; Luísa Cortes; Sandra D. Santos; Patricio O. Opazo; Lyn Rosenbrier Ribeiro; Bárbara Oliveiros; Daniel Choquet; José A. Esteban; João Peça; Ana Luísa Carvalho

doi:10.1126/scisignal.abb1953

Research ArticleNeuroscience

Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation

View ORCID ProfileLuís F. Ribeiro¹,*,†,‡,
View ORCID ProfileTatiana Catarino¹,²,*,
View ORCID ProfileMário Carvalho¹,³,*,
View ORCID ProfileLuísa Cortes¹,²,
View ORCID ProfileSandra D. Santos¹,²,
Patricio O. Opazo⁴,⁵,§,
View ORCID ProfileLyn Rosenbrier Ribeiro⁶,||,
View ORCID ProfileBárbara Oliveiros⁷,⁸,
View ORCID ProfileDaniel Choquet⁴,⁵,⁹,
View ORCID ProfileJosé A. Esteban¹⁰,
View ORCID ProfileJoão Peça ¹,¹¹, and
View ORCID ProfileAna Luísa Carvalho ¹,¹¹,‡

¹CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
²University of Coimbra, IIIUC—Institute for Interdisciplinary Research, 3030-789 Coimbra, Portugal.
³MIT-Portugal Bioengineering Systems Doctoral Program, NOVA University of Lisbon, 1099-85, Lisboa, Portugal.
⁴University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, 33000 Bordeaux, France.
⁵CNRS, UMR 5297, 33000 Bordeaux, France.
⁶Functional and Mechanistic Safety, Clinical Pharmacology and Safety Sciences, R&D AstraZeneca, Cambridge CB2 0SL, UK.
⁷Laboratory of Biostatistics and Medical Informatics (LBIM), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
⁸Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
⁹Bordeaux Imaging Center, UMS 3420, CNRS-Bordeaux University, US4 INSERM, 33000 Bordeaux, France.
¹⁰Department of Molecular Neurobiology, Centro de Biología Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid, 28049 Madrid, Spain.
¹¹University of Coimbra, Department of Life Sciences, 3000-456 Coimbra, Portugal.

↵‡Corresponding author. Email: luis.ribeiro{at}kuleuven.vib.be (L.F.R.); alc{at}cnc.uc.pt (A.L.C.)

↵* These authors contributed equally to this work.
↵† Present address: VIB Center for Brain and Disease Research, Leuven, Belgium; KU Leuven Department of Neurosciences, Leuven, Belgium.
↵§ Present address: Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, University of Queensland, St. Lucia, Queensland, Australia.
↵|| Present address: Medicines Discovery Catapult, Block 35, Mereside, Alderley Park, Alderley Edge, Macclesfield SK10 4TG, UK.

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Science Signaling 16 Feb 2021:
Vol. 14, Issue 670, eabb1953
DOI: 10.1126/scisignal.abb1953

Luís F. Ribeiro

1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

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For correspondence: luis.ribeiro@kuleuven.vib.be alc@cnc.uc.pt

Tatiana Catarino

1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

2University of Coimbra, IIIUC—Institute for Interdisciplinary Research, 3030-789 Coimbra, Portugal.

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Mário Carvalho

1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

3MIT-Portugal Bioengineering Systems Doctoral Program, NOVA University of Lisbon, 1099-85, Lisboa, Portugal.

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Luísa Cortes

1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

2University of Coimbra, IIIUC—Institute for Interdisciplinary Research, 3030-789 Coimbra, Portugal.

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Sandra D. Santos

1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

2University of Coimbra, IIIUC—Institute for Interdisciplinary Research, 3030-789 Coimbra, Portugal.

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Patricio O. Opazo

4University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, 33000 Bordeaux, France.

5CNRS, UMR 5297, 33000 Bordeaux, France.

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Lyn Rosenbrier Ribeiro

6Functional and Mechanistic Safety, Clinical Pharmacology and Safety Sciences, R&D AstraZeneca, Cambridge CB2 0SL, UK.

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Bárbara Oliveiros

7Laboratory of Biostatistics and Medical Informatics (LBIM), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

8Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

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Daniel Choquet

4University of Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, 33000 Bordeaux, France.

5CNRS, UMR 5297, 33000 Bordeaux, France.

9Bordeaux Imaging Center, UMS 3420, CNRS-Bordeaux University, US4 INSERM, 33000 Bordeaux, France.

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José A. Esteban

10Department of Molecular Neurobiology, Centro de Biología Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid, 28049 Madrid, Spain.

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João Peça

1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

11University of Coimbra, Department of Life Sciences, 3000-456 Coimbra, Portugal.

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Ana Luísa Carvalho

1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

11University of Coimbra, Department of Life Sciences, 3000-456 Coimbra, Portugal.

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For correspondence: luis.ribeiro@kuleuven.vib.be alc@cnc.uc.pt

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