A predictive model of gene expression reveals the role of network motifs in the mating response of yeast

Amy E. Pomeroy; Matthew I. Peña; John R. Houser; Gauri Dixit; Henrik G. Dohlman; Timothy C. Elston; Beverly Errede

doi:10.1126/scisignal.abb5235

Research ArticleSystems Biology

A predictive model of gene expression reveals the role of network motifs in the mating response of yeast

View ORCID ProfileAmy E. Pomeroy ¹,†,
View ORCID ProfileMatthew I. Peña²,*,†,
John R. Houser²,
Gauri Dixit³,
View ORCID ProfileHenrik G. Dohlman ³,
View ORCID ProfileTimothy C. Elston ²,⁴,‡, and
View ORCID ProfileBeverly Errede ³,‡

¹Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
²Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
³Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
⁴Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

↵‡Corresponding author. Email: errede{at}email.unc.edu (B.E.); telston{at}med.unc.edu (T.C.E.)

↵* Present address: Department of BioSciences, Rice University, Houston, TX 77005, USA.
↵† These authors contributed equally to this work.

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Science Signaling 16 Feb 2021:
Vol. 14, Issue 670, eabb5235
DOI: 10.1126/scisignal.abb5235

Amy E. Pomeroy

1Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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ORCID record for Amy E. Pomeroy

Matthew I. Peña

2Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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John R. Houser

2Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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Gauri Dixit

3Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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Henrik G. Dohlman

3Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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ORCID record for Henrik G. Dohlman

Timothy C. Elston

2Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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For correspondence: errede@email.unc.edu telston@med.unc.edu

Beverly Errede

3Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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ORCID record for Beverly Errede
For correspondence: errede@email.unc.edu telston@med.unc.edu

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vol. 14 no. 670

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https://doi.org/10.1126/scisignal.abb5235

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Received March 3, 2020
Accepted January 8, 2021
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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works https://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

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A predictive model of gene expression reveals the role of network motifs in the mating response of yeast

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