Research ArticleCancer

Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression

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Science Signaling  06 Apr 2021:
Vol. 14, Issue 677, eaax5971
DOI: 10.1126/scisignal.aax5971

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MPO mitigates melanoma

Myeloid cells such as neutrophils and macrophages generate hypochlorous acid (HOCl) through the enzymatic activity of myeloperoxidase (MPO) to kill microbes. Liu et al. found that HOCl generated by MPO in myeloid cells inhibited the early development of subcutaneous melanoma tumors by suppressing NF-κB activity in tumor cells. The authors simultaneously imaged MPO activity in myeloid cells and IκB kinase activity (the upstream activator of NF-κB) in B16F10 melanoma cells subcutaneously implanted into mice. HOCl promoted a transcriptional profile in CD8+ T cells associated with T cell activation and in B16F10 cells, suggestive of an antioxidant response. Thus, MPO in myeloid cells has antitumor effects during the early stages of melanoma growth.

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