Research ArticleCancer Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression View ORCID ProfileTracy W. Liu1, View ORCID ProfileSeth T. Gammon1, Ping Yang1, View ORCID ProfileDavid Fuentes2, and View ORCID ProfileDavid Piwnica-Worms1,*1Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.2Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.↵*Corresponding author. Email: dpiwnica-worms{at}mdanderson.org See allHide authors and affiliations Science Signaling 06 Apr 2021:Vol. 14, Issue 677, eaax5971DOI: 10.1126/scisignal.aax5971 Tracy W. Liu 1Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Tracy W. Liu Seth T. Gammon 1Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Seth T. Gammon Ping Yang 1Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site David Fuentes 2Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for David Fuentes David Piwnica-Worms 1Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for David Piwnica-Worms For correspondence: dpiwnica-worms@mdanderson.org Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 14 no. 677 DOI: https://doi.org/10.1126/scisignal.aax5971 PubMed: 33824181 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received April 5, 2019Resubmitted January 27, 2020Accepted February 25, 2021 . Copyright & Usage: Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works https://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License. Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: April 2021 to April 2021 AbstractFullPdf Apr 20213839439118 View Full Text
Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression By Tracy W. Liu, Seth T. Gammon, Ping Yang, David Fuentes, David Piwnica-Worms Science Signaling06 Apr 2021 MPO in host myeloid cells has antitumor effects during the early stages of melanoma growth. Supplementary Materials
Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression By Tracy W. Liu, Seth T. Gammon, Ping Yang, David Fuentes, David Piwnica-Worms Science Signaling06 Apr 2021 MPO in host myeloid cells has antitumor effects during the early stages of melanoma growth. Supplementary Materials