Research ArticleNeuroscience

Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu2/mGlu4 receptor heterodimers

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Science Signaling  06 Apr 2021:
Vol. 14, Issue 677, eabd2319
DOI: 10.1126/scisignal.abd2319

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Synapse-specific partnership

Neurotransmission between the thalamus and medial prefrontal cortex (mPFC) in the brain regulates working memory and goal-directed and social dominance behaviors. Increased activity at synapses between the thalamus and the mPFC is implicated in some symptoms of schizophrenia and is attributed in part to reduced activity of the metabotropic glutamate receptor mGluR2. Using selective pharmacological agents on mouse brain slices, Xiang et al. found that mGluR2 formed functional heterodimers with mGluR4 selectively at inputs from the thalamus to the mPFC, but not those from the hippocampus or amygdala, which regulate other critical cognitive functions. The findings could lead to highly targeted treatments for a set of behaviors associated with schizophrenia and related disorders.

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