Contents
06 April 2021
Vol 14, Issue 677
Vol 14, Issue 677
Research Articles
- Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression
MPO in host myeloid cells has antitumor effects during the early stages of melanoma growth.
- Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu2/mGlu4 receptor heterodimers
A specific metabotropic glutamate receptor heterodimer selectively regulates thalamic input to the prefrontal cortex.
Review
- Biased ligands at opioid receptors: Current status and future directions
Ongoing efforts to identify and characterize biased ligands for opioid receptors are discussed.
Editors' Choice
- ARC unleashes elastase
An antiapoptotic cytoplasmic protein becomes a proapoptotic nuclear protein in diabetes.
About The Cover
Online Cover This week features a Research Article that shows that the production of the chlorinating oxidant HOCl by the enzyme MPO in host myeloid cells limits early melanoma growth. The image shows hematoxylin and eosin staining of a tumor in an MPO–/– mouse. [Image: Tracy Liu and David Piwnica-Worms/Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, USA]
