06 July 2021
Vol 14, Issue 690
  • Research Article

    • Long-chain polyphosphates impair SARS-CoV-2 infection and replication

      Long-chain polyphosphates inhibit SARS-CoV-2 infection by targeting a host receptor and a viral RNA polymerase.

  • Research Resource

  • Editors' Choice

    • Complex CAFs

      Diversity among cancer-associated fibroblasts from cholangiocarcinomas reveals distinct roles in tumor progression.

About The Cover

Cover image expansion

Online Cover This week features two papers related to COVID-19. In a Research Resource, Cai et al. performed a metabolomics analysis that showed that compared to female COVID-19 patients, male COVID-19 patients have more of the metabolite kynurenic acid in their serum, which may underlie sex-specific immune responses to SARS-CoV-2 infection. In a Research Article, Ferrucci et al. showed that long-chain polyphosphates inhibit SARS-CoV-2 infection and replication by targeting a cell surface receptor and a viral RNA polymerase. The image is a colorized scanning electron micrograph of an apoptotic cell (teal) infected with SARS-COV-2 virus particles (purple), isolated from a patient sample. [Image: NIAID/Science Source]