All Good Things Must Come to an End: How Is Notch Signaling Turned off?

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Science's STKE  23 Nov 1999:
Vol. 1999, Issue 9, pp. pe1
DOI: 10.1126/stke.1999.9.pe1

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  • Is it all about Tramtrack?

    A potential target for proteasome degradation in the sensory organ precursor (SOP) may have been inadvertently described elsewhere. Dong et al. (1) identified the protein tramtrack (Ttk) as a target for proteasome mediated degradation. Like Enhancer of Split (Espl), ttk is a transcriptional target of Notch signaling (2-4) and it mediates the antineurogenic activity of Notch in the support cells of the SOP. Ttk...

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    Competing Interests: None declared.

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