Contents
Vol 2, Issue 100
Contents
Research Articles
- Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction
Cells addicted to different oncogenic receptor tyrosine kinases develop common downstream mechanisms to sustain malignancy.
- Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection
Apoptotic endothelial cells release microRNA-containing microvesicles to modulate the responses of neighboring cells and reduce atherosclerosis in mice.
Review
- Cracking the Phosphatase Code: Docking Interactions Determine Substrate Specificity
Studies of the motifs that guide interactions between phosphatases and cellular proteins provide insight into phosphatase selectivity.
Journal Club
- To Be γδ or Not to Be γδ? Signaling Pathways in αβ Versus γδ T Cell Maturation
The role of Notch signaling in human T cell maturation is substantially different from that in the mouse.
Editors' Choice
- Channeling Your Fear
An acid-sensitive channel in the brain promotes fear responses to CO2.
- Those Irritating Acellular Mitochondria
Particular causes of cellular necrosis trigger an innate inflammatory response that involves the mitochondria of the necrotic cell.
- RANKLed About Fevers?
RANKL-RANK signaling mediates the central fever response to inflammatory cytokines and plays a role in female thermoregulation.
- Lipids Link Membrane Molecules
Patched-mediated modulation of membrane lipid composition may regulate Smoothened trafficking.
- ABA Receptor Up Close
The plant hormone responsible for drought tolerance signals by inducing conformational changes in its dimeric protein receptor.
- Better Alzheimer’s Options
Drugs that specifically antagonize NMDA receptors with the NR2B subunit prevent Aβ-mediated inhibition of long-term potentiation.
- An Ancient Association
Homologs of noncore components of vertebrate hedgehog signaling are required for cilia function in planarians, suggesting an ancestral association between Hh signaling components and cilia.
- Medulloblastoma and Atoh1
A transcription factor regulates signaling in the developing mouse cerebellum and also influences cancer formation.
- Metamorphosis Signal Reception
The neuropeptide PTTH initiates metamorphosis in the fruit fly through the receptor tyrosine kinase Torso.
Erratum
