Contents

Contents

• Research Articles

  • Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction

    By Andrea Bertotti, Mike F. Burbridge, Stefania Gastaldi, Francesco Galimi, Davide Torti, Enzo Medico, Silvia Giordano, Simona Corso, Gaëlle Rolland-Valognes, Brian P. Lockhart, John A. Hickman, Paolo M. Comoglio, Livio Trusolino

    Science Signaling08 Dec 2009 : ra80 Full AccessRestricted Access

    Cells addicted to different oncogenic receptor tyrosine kinases develop common downstream mechanisms to sustain malignancy.

    • Editor's Summary
    • Abstract
    • Full Text
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  • Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

    By Alma Zernecke, Kiril Bidzhekov, Heidi Noels, Erdenechimeg Shagdarsuren, Lin Gan, Bernd Denecke, Mihail Hristov, Thomas Köppel, Maliheh Nazari Jahantigh, Esther Lutgens, Shusheng Wang, Eric N. Olson, Andreas Schober, Christian Weber

    Science Signaling08 Dec 2009 : ra81 Full AccessRestricted Access

    Apoptotic endothelial cells release microRNA-containing microvesicles to modulate the responses of neighboring cells and reduce atherosclerosis in mice.

    • Editor's Summary
    • Abstract
    • Full Text
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• Review

  • Cracking the Phosphatase Code: Docking Interactions Determine Substrate Specificity

    By Jagoree Roy, Martha S. Cyert

    Science Signaling08 Dec 2009 : re9 Full AccessRestricted Access

    Studies of the motifs that guide interactions between phosphatases and cellular proteins provide insight into phosphatase selectivity.

    • Abstract
    • Full Text
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• Journal Club

  • To Be γδ or Not to Be γδ? Signaling Pathways in αβ Versus γδ T Cell Maturation

    By Julia K. Archbold

    Science Signaling08 Dec 2009 : jc2 Full AccessRestricted Access

    The role of Notch signaling in human T cell maturation is substantially different from that in the mouse.

    • Abstract
    • Full Text
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• Editors' Choice

  • Channeling Your Fear

    By L. Bryan Ray

    Science Signaling08 Dec 2009 : ec387 Full AccessRestricted Access

    An acid-sensitive channel in the brain promotes fear responses to CO₂.

    • Abstract

  • Those Irritating Acellular Mitochondria

    By Nancy R. Gough

    Science Signaling08 Dec 2009 : ec388 Full AccessRestricted Access

    Particular causes of cellular necrosis trigger an innate inflammatory response that involves the mitochondria of the necrotic cell.

    • Abstract

  • RANKLed About Fevers?

    By Elizabeth M. Adler

    Science Signaling08 Dec 2009 : ec389 Full AccessRestricted Access

    RANKL-RANK signaling mediates the central fever response to inflammatory cytokines and plays a role in female thermoregulation.

    • Abstract

  • Lipids Link Membrane Molecules

    By Annalisa M. VanHook

    Science Signaling08 Dec 2009 : ec390 Full AccessRestricted Access

    Patched-mediated modulation of membrane lipid composition may regulate Smoothened trafficking.

    • Abstract

  • ABA Receptor Up Close

    By Pamela Hines

    Science Signaling08 Dec 2009 : ec391 Full AccessRestricted Access

    The plant hormone responsible for drought tolerance signals by inducing conformational changes in its dimeric protein receptor.

    • Abstract

  • Better Alzheimer’s Options

    By Nancy R. Gough

    Science Signaling08 Dec 2009 : ec392 Full AccessRestricted Access

    Drugs that specifically antagonize NMDA receptors with the NR2B subunit prevent Aβ-mediated inhibition of long-term potentiation.

    • Abstract

  • An Ancient Association

    By Annalisa M. VanHook

    Science Signaling08 Dec 2009 : ec393 Full AccessRestricted Access

    Homologs of noncore components of vertebrate hedgehog signaling are required for cilia function in planarians, suggesting an ancestral association between Hh signaling components and cilia.

    • Abstract

  • Medulloblastoma and Atoh1

    By Pamela Hines

    Science Signaling08 Dec 2009 : ec394 Full AccessRestricted Access

    A transcription factor regulates signaling in the developing mouse cerebellum and also influences cancer formation.

    • Abstract

  • Metamorphosis Signal Reception

    By Annalisa M. VanHook

    Science Signaling08 Dec 2009 : ec395 Full AccessRestricted Access

    The neuropeptide PTTH initiates metamorphosis in the fruit fly through the receptor tyrosine kinase Torso.

    • Abstract

• Erratum

  • A Correction to the Perspective Titled: "A New Mechanism of Phosphoregulation in Signal Transduction Pathways" by K. Jung and H. Jung

    Science Signaling08 Dec 2009 : er10 Full AccessRestricted Access

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