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vol. 2 no. 100 ra80
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History:
- Received September 15, 2009
- Accepted November 18, 2009
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Copyright © 2009, American Association for the Advancement of Science
Research ArticleCancer Biology
Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction
- Andrea Bertotti1,
- Mike F. Burbridge2,*,
- Stefania Gastaldi1,*,
- Francesco Galimi1,*,
- Davide Torti1,*,
- Enzo Medico3,
- Silvia Giordano1,
- Simona Corso1,
- Gaëlle Rolland-Valognes4,
- Brian P. Lockhart4,
- John A. Hickman2,
- Paolo M. Comoglio1,†, and
- Livio Trusolino1,†
- 1Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
- 2Cancer Research and Drug Discovery, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.
- 3Laboratory of Functional Genomics, The Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
- 4Division of Molecular Pharmacology and Pathophysiology, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.
- ↵†To whom correspondence should be addressed. E-mail: livio.trusolino{at}ircc.it (L.T.) and paolo.comoglio{at}ircc.it (P.M.C.)
-
↵* These authors contributed equally to this work.
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Science Signaling 08 Dec 2009:
Vol. 2, Issue 100, pp. ra80
DOI: 10.1126/scisignal.2000643
Vol. 2, Issue 100, pp. ra80
DOI: 10.1126/scisignal.2000643
Andrea Bertotti
Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
Mike F. Burbridge
Cancer Research and Drug Discovery, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.
Stefania Gastaldi
Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
Francesco Galimi
Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
Davide Torti
Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
Enzo Medico
Laboratory of Functional Genomics, The Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
Silvia Giordano
Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
Simona Corso
Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
Gaëlle Rolland-Valognes
Division of Molecular Pharmacology and Pathophysiology, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.
Brian P. Lockhart
Division of Molecular Pharmacology and Pathophysiology, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.
John A. Hickman
Cancer Research and Drug Discovery, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.
Paolo M. Comoglio
Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
Livio Trusolino
Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
