Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction

Andrea Bertotti; Mike F. Burbridge; Stefania Gastaldi; Francesco Galimi; Davide Torti; Enzo Medico; Silvia Giordano; Simona Corso; Gaëlle Rolland-Valognes; Brian P. Lockhart; John A. Hickman; Paolo M. Comoglio; Livio Trusolino

doi:10.1126/scisignal.2000643

Research ArticleCancer Biology

Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction

Andrea Bertotti¹,
Mike F. Burbridge²,*,
Stefania Gastaldi¹,*,
Francesco Galimi¹,*,
Davide Torti¹,*,
Enzo Medico³,
Silvia Giordano¹,
Simona Corso¹,
Gaëlle Rolland-Valognes⁴,
Brian P. Lockhart⁴,
John A. Hickman²,
Paolo M. Comoglio¹,^†, and
Livio Trusolino¹,^†

¹Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
²Cancer Research and Drug Discovery, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.
³Laboratory of Functional Genomics, The Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.
⁴Division of Molecular Pharmacology and Pathophysiology, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.

↵†To whom correspondence should be addressed. E-mail: livio.trusolino{at}ircc.it (L.T.) and paolo.comoglio{at}ircc.it (P.M.C.)

↵* These authors contributed equally to this work.

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Science Signaling 08 Dec 2009:
Vol. 2, Issue 100, pp. ra80
DOI: 10.1126/scisignal.2000643

Andrea Bertotti

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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Mike F. Burbridge

Cancer Research and Drug Discovery, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.

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Stefania Gastaldi

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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Francesco Galimi

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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Davide Torti

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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Enzo Medico

Laboratory of Functional Genomics, The Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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Silvia Giordano

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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Simona Corso

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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Gaëlle Rolland-Valognes

Division of Molecular Pharmacology and Pathophysiology, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.

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Brian P. Lockhart

Division of Molecular Pharmacology and Pathophysiology, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.

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John A. Hickman

Cancer Research and Drug Discovery, Institut de Recherches Servier, 78290 Croissy-sur-Seine, France.

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Paolo M. Comoglio

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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For correspondence: livio.trusolino@ircc.it paolo.comoglio@ircc.it

Livio Trusolino

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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For correspondence: livio.trusolino@ircc.it paolo.comoglio@ircc.it

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