Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

Alma Zernecke; Kiril Bidzhekov; Heidi Noels; Erdenechimeg Shagdarsuren; Lin Gan; Bernd Denecke; Mihail Hristov; Thomas Köppel; Maliheh Nazari Jahantigh; Esther Lutgens; Shusheng Wang; Eric N. Olson; Andreas Schober; Christian Weber

doi:10.1126/scisignal.2000610

Research ArticleATHEROSCLEROSIS

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

Alma Zernecke¹,²,*,†,
Kiril Bidzhekov¹,*,
Heidi Noels¹,*,
Erdenechimeg Shagdarsuren¹,
Lin Gan³,
Bernd Denecke³,
Mihail Hristov¹,
Thomas Köppel⁴,
Maliheh Nazari Jahantigh¹,
Esther Lutgens¹,⁵,
Shusheng Wang⁶,
Eric N. Olson⁶,
Andreas Schober¹, and
Christian Weber¹,⁵,†

¹Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.
²Rudolf-Virchow-Center–DFG Research Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
³Interdisciplinary Centre for Clinical Research BIOMAT, Department of Vascular Surgery, RWTH Aachen University, 52074 Aachen, Germany.
⁴Department of Vascular Surgery, RWTH Aachen University, 52074 Aachen, Germany.
⁵Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, 6200 MD Maastricht, the Netherlands.
⁶Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390–9148, USA.

↵†To whom correspondence should be addressed. E-mail: cweber{at}ukaachen.de (C.W.) and alma.zernecke{at}virchow.uni-wuerzburg.de (A.Z.)

↵* These authors contributed equally to this work.

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Science Signaling 08 Dec 2009:
Vol. 2, Issue 100, pp. ra81
DOI: 10.1126/scisignal.2000610

Alma Zernecke

1Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.

2Rudolf-Virchow-Center–DFG Research Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.

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For correspondence: cweber@ukaachen.de alma.zernecke@virchow.uni-wuerzburg.de

Kiril Bidzhekov

1Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.

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Heidi Noels

1Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.

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Erdenechimeg Shagdarsuren

1Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.

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Lin Gan

3Interdisciplinary Centre for Clinical Research BIOMAT, Department of Vascular Surgery, RWTH Aachen University, 52074 Aachen, Germany.

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Bernd Denecke

3Interdisciplinary Centre for Clinical Research BIOMAT, Department of Vascular Surgery, RWTH Aachen University, 52074 Aachen, Germany.

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Mihail Hristov

1Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.

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Thomas Köppel

4Department of Vascular Surgery, RWTH Aachen University, 52074 Aachen, Germany.

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Maliheh Nazari Jahantigh

1Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.

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Esther Lutgens

1Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.

5Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, 6200 MD Maastricht, the Netherlands.

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Shusheng Wang

6Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390–9148, USA.

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Eric N. Olson

6Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390–9148, USA.

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Andreas Schober

1Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.

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Christian Weber

1Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.

5Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, 6200 MD Maastricht, the Netherlands.

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For correspondence: cweber@ukaachen.de alma.zernecke@virchow.uni-wuerzburg.de

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Apoptotic endothelial cells release microRNA-containing microvesicles to modulate the responses of neighboring cells and reduce atherosclerosis in mice.

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

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