Contents
Vol 2, Issue 101
Contents
Research Articles
- EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy
Inhibitors of fatty acid signaling promote apoptosis in glioblastoma cells with highly active EGFR signaling.
- Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation
The guanine nucleotide exchange activity of Vav1 is required for some, but not all, of its functions in T cell development, activation, and signaling.
Perspectives
- Cell Mechanics and Feedback Regulation of Actomyosin Networks
Mechanical signals shape the organization and dynamics of contractile networks in cells during morphogenesis.
- Making Sense of Signal Transduction
Textbook provides an overview of signaling concepts and models for teaching.
Podcast
- Science Signaling Podcast: 15 December 2009
Inhibiting fatty acid synthesis may be effective in controlling glioblastomas driven by EGFR signaling.
Editors' Choice
- Evolution of Metabolic Diseases
Integration of ancestral immune responses with mobilization of energy stores provides clues to understanding metabolic diseases in humans.
- It’s All Relative
As long as the fold change in the signal remains the same, the output of the signaling network is robust to changes in the absolute amount of the signal.
- Exciting Structures
The solution to the structure of the AMPA receptor reveals clues about the general mechanisms of action of ionotropic glutamate receptors.
- Stressed About Atherosclerosis?
Toxic lipids elicit macrophage endoplasmic stress through aP2.
- Dissecting Ephrin-Receptor Interaction
A proteomic strategy elucidates signaling networks between cells communicating through ephrin proteins and their receptors.
- Norbin Knockout
The protein Norbin regulates the accumulation of a neurotransmitter receptor in mouse brain cell membranes.
- An Innervative Small RNA
A small noncoding RNA promotes nerve-muscle interactions in response to motor neuron injury and slows disease progression.
