Contents
Vol 2, Issue 52
Contents
Editorial Guide
- 2008: Signaling Breakthroughs of the Year
The signaling breakthroughs of 2008 extended from protein crystals to cells and subcellular structures to whole genomes.
Perspectives
- MicroRNAs: Opening a New Vein in Angiogenesis Research
MicroRNAs regulate angiogenic signaling in endothelial cells.
- Computational Implications of Cooperative Plasticity Induction at Nearby Dendritic Sites
Cooperative interactions at nearby synapses may endow individual neurons with computational functions.
Journal Club
- Drosophila Toll Pathway: The New Model
New data has led to reevaluation of the proteolytic cascades that activate Toll in flies.
Editors' Choice
- The Long Way Around
Leptin decreases insulin production in part by inhibiting the activity of the insulin secretagogue osteocalcin in an epinephrine-dependent manner.
- Adaptive Inflammation
Inflammation is critical to inward vascular remodeling after hemodynamic changes.
- Roads to Death City
Genome-wide RNAi screen reveals genes involved in necroptosis, a form of necrotic cell death.
- Cone of Inactivation
Rho GTPase activity in pollen tubes is restricted to the apical tip by a Rho GAP that is present throughout the apical region.
- Keeping Fungal Invaders at Bay
Plant cells defend against fungal attack through an innate immunity pathway in which infection triggers glucosinolate synthesis, stimulating formation of a protective callose.
- Scaffolding Through Phosphatidic Acid–Enriched Domains
The interaction of multiple components of the mitogen-activated protein kinase cascade with phosphatidic acid contributes to activation at the membrane.
- Right on Target
Newly made proteins destined to be inserted into membranes trigger an RNA switch that promotes initiation of this process.
- Chaperone to Neurodegeneration
The degradation of a key neuronal survival factor by chaperone-mediated autophagy may contribute to Parkinson's disease.
- How Macrophages Make Metastases
Tumor cells make a proteoglycan that stimulates macrophages to help promote metastasis.
