06 January 2009
Vol 2, Issue 52
  • Contents

    • Editorial Guide

    • Perspectives

    • Journal Club

    • Editors' Choice

      • The Long Way Around

        Leptin decreases insulin production in part by inhibiting the activity of the insulin secretagogue osteocalcin in an epinephrine-dependent manner.

      • Adaptive Inflammation

        Inflammation is critical to inward vascular remodeling after hemodynamic changes.

      • Roads to Death City

        Genome-wide RNAi screen reveals genes involved in necroptosis, a form of necrotic cell death.

      • Cone of Inactivation

        Rho GTPase activity in pollen tubes is restricted to the apical tip by a Rho GAP that is present throughout the apical region.

      • Keeping Fungal Invaders at Bay

        Plant cells defend against fungal attack through an innate immunity pathway in which infection triggers glucosinolate synthesis, stimulating formation of a protective callose.

      • Right on Target

        Newly made proteins destined to be inserted into membranes trigger an RNA switch that promotes initiation of this process.

      • Chaperone to Neurodegeneration

        The degradation of a key neuronal survival factor by chaperone-mediated autophagy may contribute to Parkinson's disease.

      • How Macrophages Make Metastases

        Tumor cells make a proteoglycan that stimulates macrophages to help promote metastasis.

About The Cover

Cover image expansion

COVER To start the New Year, this week's Editorial Guide highlights research in 2008 that we consider to be Signaling Breakthroughs. Breakthroughs this year crossed a broad range of fields, including neuroscience, immunology, systems biology, and plant biology, and spanned the kingdoms of life. [Credit: Image Composition, Christopher Bickel, AAAS; Images and photos, Janice Carr, CDC; Jupiter Images]