20 January 2009
Vol 2, Issue 54
  • Contents

    • Perspective

    • Protocol

    • Editors' Choice

      • Staving Off Hunger

        Signaling through metabotropic glutamate receptors affects the nematode starvation response.

      • Integrins Are More Engaging in 3D

        Culture environment and presence of extracellular matrix attachments synergize to regulate the angiogenic signals that tumor cells release.

      • Draxin and Axon Guidance

        A protein cue guides the formation of bundles of nerve fibers that connect the cerebral hemispheres.

      • Escape Artists

        A persistence factor similar to a eukaryotic kinase regulates bacterial dormancy and contributes to antibiotic resistance in E. coli.

      • Nematodes Behaving Badly

        Mutations in neuropeptide receptors prevent nematode worms from swimming away to avoid bacterial pathogens.

      • How to Evolve into a Parasite

        A steroid hormone and its nuclear receptor regulate dauer formation and infectivity in larvae from different nematode species.

    • Connections Map Overview

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that discusses how protein kinases can be activated through autophosphorylation of their activation loops in cis. The image (based on PDB 1ir3) shows the crystal structure of the active state of insulin receptor kinase bound to a peptide substrate (yellow), highlighting such features as the activation loop (red), the catalytic loop (green), and the αC helix (purple). [Credit: Chris Bickel, AAAS]