Research ArticleDevelopmental Biology

Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic

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Sci. Signal.  27 Jan 2009:
Vol. 2, Issue 55, pp. ra1
DOI: 10.1126/scisignal.2000140

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Micromanaging Development

By combining microarray gene expression data with occupancy by a key DNA binding transducer in the Notch pathway, Krejčí et al. set a gold standard for target genes that are regulated directly by Notch. The analysis also reveals incoherent network logic in which Notch signaling activates both positive and negative regulators of several pathways, which may allow Notch to micromanage multiple signaling networks and poise cells for different responses depending on the context. Detailed analysis of several Notch direct target genes in vivo reveals that many of the identified genes participate in regulation of adult muscle progenitors in Drosophila.