03 February 2009
Vol 2, Issue 56
  • Contents

    • Perspectives

    • Podcast

    • Editors' Choice

      • Fat Feedback

        A receptor for lactate may mediate its effects on regulation of lipolysis.

      • Of Chloride and Quantal Size

        The vesicular glutamate transporter VGLUT1 mediates a chloride conductance and enables modulation of glutamate uptake into synaptic vesicles by intraluminal chloride concentration.

      • Different But Equal

        Binding to the high- or low-affinity site of erythropoietin does not affect the ability of its receptor to initiate intracellular signaling cascades.

      • To Swarm or Not to Swarm?

        Serotonin induces the phenotypic switch from solitary to gregarious behavior in desert locusts.

      • Calmodulin in Action

        Single-molecule force spectroscopy reveals the equilibrium dynamics of calmodulin folding and how it is modulated by peptide ligands.

      • Conducting Myelination

        Signaling through calcineurin and NFATc controls Schwann cell differentiation.

      • Amplifying the Death Signal

        S-glutathionylation of Fas promotes clustering and activation of this death receptor.

      • Innately Allergenic?

        The dust mite allergen Der p 2 interacts with the Toll-like receptor (TLR) 4 complex to promote lipopolysaccharide-driven TLR4 signaling.

      • Modeling Chemical Communication

        Communication between chemical oscillators in solution can mimic that of large populations of single-celled organisms.

      • Feeling Tense

        Mechanical forces can alter the availability of protein binding sites and regulate cell signaling.

      • Asymmetric Division in Plant Development

        Asymmetric cell division in plants is regulated by a receptor-like kinase, implicating a signaling cascade in cell polarization.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective about theoretical predictions of the mechanisms underlying synaptic plasticity that have now been experimentally verified. The image is an artist's rendition of synaptic communication. [Credit: Christopher Bickel, AAAS]