Contents
Vol 2, Issue 57
Contents
Research Article
- Brx Mediates the Response of Lymphocytes to Osmotic Stress Through the Activation of NFAT5
The guanine nucleotide exchange factor Brx is essential for osmotic stress–mediated expression of nfat5 in lymphocytes.
Meeting Report
- Emerging Roles of NAD+ and Its Metabolites in Cell Signaling
Scientists discussed the molecular aspects of NAD+ metabolism and signaling at a conference in Hamburg, Germany.
Editors' Choice
- More Substance to Excitation
The neuropeptide substance P activates the cation channel NALCN in a G protein–independent manner to evoke slow excitation of neurons.
- Transcription Factor for p75NTR
Activation of the p75NTR and the TrkA neurotrophin receptors by nerve growth factor promotes the dissociation of the transcription factor Sall2 from the p75NTR, cell cycle arrest, and neurite outgrowth.
- Doing the Glutamine Two-Step
The ability of essential amino acids to enter cells and activate mTORC1 signaling depends on their exchange for glutamine.
- Broken Blood Vessels
The signaling pathway mediated by the cerebral cavernous malformation protein 2 functions in endothelial cells to regulate angiogenesis.
- Mitochondrial Stat3 Activity
A protein that has a nuclear function as a transcription factor also functions to support respiration in the mitochondria.
- Yet Another Ubiquitin Arrangement for NF-κB
Linear polyubiquitylation of NEMO bypasses the need for Lys63-linked ubiquitylation in activating nuclear factor κB in response to tumor necrosis factor–α.
- Counting Centrosomes
A DNA replication factor ensures that only two centrioles are formed during cell division in animal cells.
- Working Memory and Dopamine
Training of working memory alters brain biochemistry by changing the density of cortical dopamine receptors.
- Axonal Regeneration in Nematodes
Axon regeneration in adult nematode worms has distinct signals that are independent of earlier developmental programs.
- Water in the Brain
The growth factor erythropoietin can prevent swelling associated with brain injury.
