Contents
Vol 2, Issue 59
Contents
Research Articles
- Dok-7 Activates the Muscle Receptor Kinase MuSK and Shapes Synapse Formation
The cytoplasmic protein Dok-7 is required for the full activation of the receptor tyrosine kinase MuSK.
- IL-17 Receptor Signaling Inhibits C/EBPβ by Sequential Phosphorylation of the Regulatory 2 Domain
The IL-17 receptor triggers dual, sequential phosphorylation of the transcription factor C/EBPβ, which represses the expression of target genes.
Perspectives
- Jasmonate: Preventing the Maize Tassel from Getting in Touch with His Feminine Side
Male identity in the maize tassel is controlled by jasmonate signaling.
- Chemoattractant Receptors and Leukocyte Recruitment: More Than Cell Migration
Atypical “chemoattractant receptors” that do not signal through G proteins contribute to leukocyte recruitment through indirect mechanisms.
Review
- Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands
PlGF and VEGF-B exhibit dual effects on angiogenesis mediated by VEGF-A.
Meeting Report
- Signal Transduction Molecules as Targets for Cancer Prevention
Two conferences at The Hormel Institute highlight early intervention and chemoprevention in targeting cancer.
Editors' Choice
- Death Fragment
An amyloid precursor protein (APP)–derived protein binds to DR6 to trigger axonal degeneration and neuronal cell death in response to neurotrophic factor deprivation.
- The Timing Is in the Genes
mRNA stability determines when genes are expressed in response to tumor necrosis factor.
- Breaching the Barrier
Cytokine signaling induces blood-testis barrier permeability by promoting endocytosis of membrane proteins.
- Pathways Talk at Endosomes
Epidermal growth factor receptor signaling controls the activity of Wnt and Notch pathways by regulating endosomal trafficking.
- Both a Transcription Factor and a Phosphatase
The transcription factor Eya has a distinct role as a cytoplasmic phosphatase.
- Nuclear Glutaredoxin Promotes Petals
The glutaredoxin ROXY1 controls petal formation by regulating the activity of transcription factors of the TGA family.
- Differential Aging
A logic circuit involving microRNA and transcription factors ensures the timely demise of plant leaves.
- Digital Feedback
Three signaling pathways intersect to regulate vertebrate limb patterning.
- Inverse Agonist to the Rescue
Inhibiting signaling by the β2-adrenergic receptor inhibits development of asthma in mice.
- Drooling Over Purinergic Receptors
ATP stimulates fluid secretion in mouse salivary glands through the P2X7 receptor.
- Caloric Intake and Stress Relief?
The longevity factor SIRT1 influences protein stability by keeping heat shock factor 1 in its active state.
