Contents
Vol 2, Issue 60
Contents
Research Article
- Odor Coding by a Mammalian Receptor Repertoire
Identification of mammalian olfactory receptor agonists enables development of a predictive model of receptor activation.
Perspective
- How Perfect Can Protein Interactomes Be?
Evolutionary noise in protein-protein interactions implies that not all interactions must be functional.
Podcast
- Science Signaling Podcast: 03 March 2009
Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma.
Editors' Choice
- Endogenous Antisense Increases p53
Expression of an antisense transcript that overlaps with the first exon of p53 increases the abundance of p53.
- Greasing the Path?
Lipids relieve open channel block of TRPL and NMDA channels by modulating membrane properties.
- Astrocytes in Alzheimer's
In a mouse model of Alzheimer's disease, astrocytes respond globally to plaque formation.
- Encoding Hypertrophy Separately from Contraction
Autocrine endothelin-1 signaling triggers a calcium signal in the nuclear region that contributes to hypertrophy of heart cells.
- Signaling al Dente
The transcription factors Msx1 and Osr2 control the distribution of BMP4 to restrict tooth development to a single row in mammals.
- BMPed into an Endocytic Sink Trap
A regulator of bone morphogenetic protein switches from enhancing to inhibiting activity at high concentrations.
- From Model to Marker
A developmental marker in fruit flies also acts as a marker of renal cell cancer in humans.
- MicroRNA Keeps Inflammation in Check
A negative feedback loop mediated by microRNA prevents excessive inflammation when dendritic cells encounter foreign stimuli.
Erratum
