Contents
Vol 2, Issue 62
Contents
Research Article
- Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR
Chronic activation of Akt and mammalian target of rapamycin (mTOR) links diet-induced obesity with cardiovascular disease.
Perspective
- Bacterial FIC Proteins AMP Up Infection
A bacterial protein posttranslationally modifies and inactivates Rho family GTPases in host cells.
Teaching Resource
- Measurement of Phosphorylated Extracellular Signal–Regulated Kinase 1 and 2 in an Undergraduate Teaching Laboratory with ALPHAscreen Technology
Students use a high-throughput assay to monitor cellular responses to receptor activation.
Editors' Choice
- Back to the Dead
Treating estrogen receptor α (ERα)–negative tumor cells with Wnt-5a restores ERα and renders them susceptible to tamoxifen-induced death.
- Stalled at Endosomes
Hypoxic conditions or forced stabilization of HIF-2α inhibits epidermal growth factor receptor delivery to lysosomes.
- Plugging In Motoneurons
A Wnt ligand acting through a receptor tyrosine kinase restricts neuromuscular junctions to the central muscle zone.
- Limiting Potential
The protein RSY-1 inhibits synapse formation by antagonizing assembly molecules during presynaptic development.
- Check Out the Checkpoint
Electron microscopy captures cell cycle checkpoint proteins in the act of inhibiting cell division in HeLa cells.
- Closing the Loop
The transcription factor CHE binds the promoter of the clock gene CCA1, adding to the molecular clock circuitry in plants.
- Paternal Influences on Zygote Development
Transcripts of a cytoplasmic gene from sperm are translated after fertilization and control asymmetric zygotic division.
- Immunological Balancing Act
Suppressor T cells selectively differentiate into helper T cells in the mouse gut and thereby promote immune homeostasis.
- From PINK(1) to Code Red
Impaired calcium regulation in the mitochondria can account for increased neuronal cell death in a model of Parkinson’s disease.
