Contents
Vol 2, Issue 63
Contents
Research Articles
- An Intramolecular Switch Regulates Phosphoindependent FHA Domain Interactions in Mycobacterium tuberculosis
Binding of Rv1827 to target proteins through its forkhead-associated (FHA) domain does not require their prior phosphorylation at threonine residues.
- Dynamic Signaling in the Hog1 MAPK Pathway Relies on High Basal Signal Transduction
High intrinsic basal signaling in mitogen-activated protein kinase pathways ensures proper dynamic responses to environmental stimuli.
Perspectives
- Challenges and Opportunities in Defining the Essential Cancer Kinome
RNAi screens for essential kinases reveal that the potential therapeutic kinase universe is larger than expected.
- Amyloid Goes Global
Amyloid plaques have farther-reaching effects on astrocytes than previously suspected.
Meeting Report
- Signal Transduction—Receptors, Mediators, and Genes
Cell signaling researchers gathered in Weimar, Germany, for the annual meeting of the Signal Transduction Society.
Presentation
- Early Events of B Cell Activation by Antigen
B cells undergo membrane spreading and contraction during activation in response to antigen-presenting cells.
Podcast
- Science Signaling Podcast: 24 March 2009
The activity of a bacterial FHA domain–containing protein is regulated intramolecularly.
Editors' Choice
- An Al-LURE-ing Guidance System
Chemoattractants that help guide growing pollen tubes in Torenia fournieri have been identified.
- Extracellular Functions of a Ribosomal Protein
When released upon cell death, ribosomal protein S19 may bind and inhibit the cytokine MIF.
- Beyond the Call of Duty
The scaffold protein Ste5 plays a coactivating role in the phosphorylation of Fus3 in the yeast mating response.
- DBLing Your Defenses
A neuronal signal involving a noncanonical TGF-β signaling pathway induces the expression of genes encoding antifungal caenacin-family peptides.
- Two-in-One Antibody
The antigen binding site of a therapeutic antibody for cancer simultaneously binds two proteins required for tumor growth.
- Sorting Light Receptors
The assembly and function of key photoreceptor proteins in neonatal mouse retinas is mediated by the protein ankyrin-G.
