An Intramolecular Switch Regulates Phosphoindependent FHA Domain Interactions in Mycobacterium tuberculosis

Timothy J. Nott; Geoff Kelly; Lasse Stach; Jiejin Li; Sarah Westcott; Dony Patel; Debbie M. Hunt; Steven Howell; Roger S. Buxton; Helen M. O’Hare; Stephen J. Smerdon

doi:10.1126/scisignal.2000212

Research ArticleBiochemistry

An Intramolecular Switch Regulates Phosphoindependent FHA Domain Interactions in Mycobacterium tuberculosis

Timothy J. Nott¹,
Geoff Kelly²,
Lasse Stach¹,
Jiejin Li¹,
Sarah Westcott¹,
Dony Patel¹,
Debbie M. Hunt³,
Steven Howell¹,
Roger S. Buxton³,
Helen M. O’Hare⁴,⁵, and
Stephen J. Smerdon¹,*

¹Division of Molecular Structure, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
²Biomedical NMR Centre, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
³Division of Mycobacterial Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
⁴Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, UK.
⁵Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.

↵*To whom correspondence should be addressed. E-mail: stephen.smerdon{at}nimr.mrc.ac.uk

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Science Signaling 24 Mar 2009:
Vol. 2, Issue 63, pp. ra12
DOI: 10.1126/scisignal.2000212

Timothy J. Nott

Division of Molecular Structure, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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Geoff Kelly

Biomedical NMR Centre, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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Lasse Stach

Division of Molecular Structure, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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Jiejin Li

Division of Molecular Structure, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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Sarah Westcott

Division of Molecular Structure, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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Dony Patel

Division of Molecular Structure, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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Debbie M. Hunt

Division of Mycobacterial Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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Steven Howell

Division of Molecular Structure, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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Roger S. Buxton

Division of Mycobacterial Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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Helen M. O’Hare

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, UK.Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.

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Stephen J. Smerdon

Division of Molecular Structure, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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For correspondence: stephen.smerdon@nimr.mrc.ac.uk

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An Intramolecular Switch Regulates Phosphoindependent FHA Domain Interactions in Mycobacterium tuberculosis

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