31 March 2009
Vol 2, Issue 64
  • Contents

    • Editorial Guide

    • Research Article

    • Perspectives

    • Editors' Choice

      • Brains Over Brawn

        A single amino acid difference accounts for the greater affinity of nicotine for the brain acetylcholine receptor compared to the muscle subtype.

      • Delivering a Toxic Message

        Some reactive estrogen metabolites may be delivered by the estrogen receptor to DNA, where they cause DNA damage.

      • Avoiding Too Much Oxygen

        Nematode responses to changes in oxygen concentration depend on the neuron-specific expression of distinct guanylate cyclases.

      • Use It or Lose It

        Wg signaling and neuronal activity cooperate to promote maintenance of Drosophila olfactory neurons.

      • Regulating Ribosomes

        A feedback loop and regulated membrane trafficking are implicated in control of ribosome biogenesis through the target of rapamycin complex 1 pathway.

      • Bringing Src to the Phosphatase

        The protein RIL, which is epigenetically silenced in some cancers, serves as an adaptor to bring active Src to the phosphatase PTPL1.

      • Inflammation Protection

        A signaling pathway involving an immune protein protects cells against the potentially fatal immune response induced by tissue damage.

      • Folding Forum

        A nine-protein transmembrane is among several hundred genes found to be critical for protein folding in the endoplasmic reticulum.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that discusses the shedding of the extracellular portion (ectodomain) of syndecan transmembrane proteoglycans. The image shows that shed syndecan ectodomains sequester the ligands for growth factor and chemokine receptors, thereby inhibiting signaling through these receptors. [Image: Preston Huey, AAAS]