Editors' ChoiceImmunology

Inflammation Protection

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Science Signaling  31 Mar 2009:
Vol. 2, Issue 64, pp. ec116
DOI: 10.1126/scisignal.264ec116

The immune system protects against infection by pathogenic microorganisms, but it also recognizes when the body has been injured. Burns, radiation exposure, and bruises all involve the immune system when responding to damaged tissue. Which signaling pathways recognize tissue damage and keep the resulting inflammatory response from getting out of hand? Chen et al. (see the Perspective by Bianchi and Manfredi) now identify CD24, a costimulatory molecule of the immune system, and the sialic-acid binding lectin, Siglec-10 (or its mouse homolog, Siglec-G), as co-receptors required for protection against the immune response induced by tissue damage, but not infection, in mice. Through association with and inhibition of the molecules that are released after tissue damage, CD24 and Siglec-G protected mice from an otherwise lethal inflammatory response.

G.-Y. Chen, J. Tang, P. Zheng, Y. Liu, CD24 and Siglec-10 selectively repress tissue damage–induced immune responses. Science 323, 1722–1725 (2009). [Abstract] [Full Text]

M. E. Bianchi, A. A. Manfredi, Dangers in and out. Science 323, 1683–1684 (2009). [Summary] [Full Text]

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