Contents
Vol 2, Issue 66
Contents
Editorial Guide
- Focus Issue: The Protein Dynamics of Cell Signaling
Changes in the conformation, binding partners, or localization of signaling proteins affect the flow of information through signaling cascades.
Research Article
- Mechanical Signals Trigger Myosin II Redistribution and Mesoderm Invagination in Drosophila Embryos
Mesoderm invagination during gastrulation is controlled by mechanical cues that promote Fog signaling and redistribution of a motor protein.
Perspectives
- Arrestin Times for Developing Antipsychotics and β-Blockers
Conformation determines G protein–independent signaling through β-arrestins.
- HIV Infection of T Cells: Actin-in and Actin-out
The coordinated activities of various actin-binding proteins facilitate entry of HIV into T cells.
Meeting Report
- Visualizing Immune System Complexity
From individual molecules to cells in animals, imaging has brought incredible insight to immunology.
Presentation
- Molecular Origin and Functional Consequences of Digital Signaling and Hysteresis During Ras Activation in Lymphocytes
Simulations, theory, and experiments reveal a potential molecular mechanism for digital signaling and short-term molecular memory in lymphocytes.
Editors' Choice
- Regulated Responses to Irregular Signals
The frequency of pulses of cytokine stimulation of a cell can determine the spectrum of genes whose transcription is regulated.
- Linking Channels and Pumps
Inhibiting Na,K-ATPase activity leads to a decrease in AMPA-type glutamate receptor abundance.
- Resistance Is Active
Tumor cells that have active PI3K signaling are resistant to the inhibitory effects of dietary restriction on tumor growth.
- The Fight or Flight of a Kinase
Calmodulin kinase II has an unexpected role in increasing heart rate in response to β-adrenergic receptor stimulation.
- Spreading AMPylation?
Fic domains from bacteria and humans can AMPylate Rho family guanosine triphosphatases.
- Mosquito Immune Mediation
A family of molecules, apparently unique to mosquitoes, binds to invading parasites and initiates innate immune responses.
- The Enzymology of Brain Cancer
Mutations in isocitrate dehydrogenase-1 compromise enzyme function and activate a signaling pathway that helps brain tumors grow when oxygen is limited.
- RNases Signal Stress
In yeast and mammalian cells, RNAses coordinate responses to stress by cleaving tRNA and through an activity-independent mechanism.
