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Abstract
Science Signaling complements the Science special issue on protein dynamics (http://www.sciencemag.org/sciext/proteindynamics/) with several articles that highlight the dynamic nature of proteins involved in signal transduction. Not only are conformational changes in proteins important for transducing signaling information, proteins also move within the cell and interact with various partners to trigger the appropriate cellular response. Examples of each of these types of protein dynamics are highlighted in this issue.