Contents
Vol 2, Issue 67
Contents
Editorial Guide
- Focus Issue: Demystifying mTOR Signaling
The field of mTOR signaling is rapidly advancing.
Perspectives
- The Pharmacology of mTOR Inhibition
The quest for effective cancer therapies reveals insight into the regulation and function of the mammalian target of rapamycin.
- Immune Regulation by Rapamycin: Moving Beyond T Cells
Rapamycin regulates immune responses, in part, through its effects on macrophages and dendritic cells.
- Akt Demoted in Glioblastoma
PKCα is an essential component of a pathway linking EGFR signaling to mTOR and cell proliferation in glioblastoma.
- New Insights into mTOR Signaling: mTORC2 and Beyond
mTORC2 promotes the phosphorylation of AGC kinase substrates at two distinct sites.
Podcast
- Science Signaling Podcast: 21 April 2009
Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling.
Editors' Choice
- DNA as an Allosteric Regulator
The sequence of the DNA binding site affects the transcriptional regulatory activity of the glucocorticoid receptor.
- Fat-Fighting Feedback
A gene-therapy–administered feedback loop restores body weight regulation in a mouse model.
- Knowing When to Stop
GABA initially serves as a promigratory signal for interneurons, then in the cortex signals the interneurons to stop.
- A Syk Response to Dead Cells
A C-type lectin links recognition of necrotic cells with activation of the adaptive immune response.
- PKD’s Gut Reaction
Protein kinase D is required by C. elegans for an effective immune response to bacterial infection in the intestine.
- Clotting Factor
Activation of PAR1 by a matrix metalloprotease mediates early thrombosis formation.
- From Quiescent to Proliferating
Acute stimulation with interferon-α promotes proliferation of hematopoietic stem cells.
- Nuts and Bolts of Chemotaxis
The signaling lipid phosphatidic acid links chemoattractant signals to directional movement of neutrophils.
- Suffocating Worms
Enzymes that catalyze synthesis of ceramide lipids influence survival of worms during anoxia.
