21 April 2009
Vol 2, Issue 67
  • Contents

    • Editorial Guide

    • Perspectives

    • Podcast

    • Editors' Choice

      • DNA as an Allosteric Regulator

        The sequence of the DNA binding site affects the transcriptional regulatory activity of the glucocorticoid receptor.

      • Fat-Fighting Feedback

        A gene-therapy–administered feedback loop restores body weight regulation in a mouse model.

      • Knowing When to Stop

        GABA initially serves as a promigratory signal for interneurons, then in the cortex signals the interneurons to stop.

      • A Syk Response to Dead Cells

        A C-type lectin links recognition of necrotic cells with activation of the adaptive immune response.

      • PKD’s Gut Reaction

        Protein kinase D is required by C. elegans for an effective immune response to bacterial infection in the intestine.

      • Clotting Factor

        Activation of PAR1 by a matrix metalloprotease mediates early thrombosis formation.

      • From Quiescent to Proliferating

        Acute stimulation with interferon-α promotes proliferation of hematopoietic stem cells.

      • Nuts and Bolts of Chemotaxis

        The signaling lipid phosphatidic acid links chemoattractant signals to directional movement of neutrophils.

      • Suffocating Worms

        Enzymes that catalyze synthesis of ceramide lipids influence survival of worms during anoxia.

About The Cover

Cover image expansion

COVER This week, Science Signaling publishes a Focus Issue on mTOR that features a collection of Perspectives and a Podcast that discuss how new pharmacological agents and knockdown of mTOR complex (mTORC)–specific subunits are providing new insights into physiological roles for mTOR signaling. The image shows the first mTOR inhibitor--rapamycin bound to FKBP-12 (PDB: 1fkb). [Image: Christopher Bickel, AAAS]