Immune Regulation by Rapamycin: Moving Beyond T Cells

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Science Signaling  21 Apr 2009:
Vol. 2, Issue 67, pp. pe25
DOI: 10.1126/scisignal.267pe25


  • Fig. 1

    Rapamycin and its structural analogs, termed rapalogs, form a complex that binds to FKBP12 to inhibit mTORC1. A simplified flowchart of signaling upstream and downstream of mTORC1 is shown at the top. The effects of rapamycin on different cell types are illustrated below. NO, nitric oxide.

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