Contents
Vol 2, Issue 68
Contents
Editorial Guide
- Omic Empiricism
Omics researchers might do well to consider the duality between empiricism and rationalism.
Research Articles
- Gαi1 and Gαi3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway
Two members of the Gαi family of G proteins form complexes with EGFR and the adaptor protein Gab1 to mediate activation of Akt.
- Ligand Binding to LRP1 Transactivates Trk Receptors by a Src Family Kinase–Dependent Pathway
Trk receptor–mediated neurite outgrowth is triggered by distinct ligands that activate LRP1.
- Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks
Analysis of protein phosphorylation patterns provides insight into the organization of molecular networks at the postsynaptic density.
Perspective
- Nontraditional Signaling Mechanisms of Lipoprotein Receptors
Lipoprotein receptors can trigger calcium-dependent kinase activation, gene transcription, or TrkA receptor-dependent signaling.
Review
- Signaling by Gasotransmitters
Nitric oxide, carbon monoxide, and hydrogen sulfide act as messengers in the cardiovascular, immune, and nervous systems.
Presentation
- Mechanobiology of the Skeleton
Mechanical force induces osteogenesis by repressing the production of sclerostin, an inhibitor of Wnt signaling.
Editors' Choice
- A Spore’s Lifeline
A cytoplasmic connection between mother cell and forespore is required for sporulation in Bacillus subtilis.
- Dragged by a Newborn Peptide
Membrane recruitment of XBP1u mRNA by its nascent polypeptide facilitates its splicing.
- Spermatogenesis Lost in Translation
An RNA-binding protein is required for spermatogenesis and enhances translation of specific mRNAs.
- Endosomes for Asymmetry
Endosomes deliver signaling molecules into the appropriate daughter cell during Drosophila sensory organ precursor division.
- Smurfed Up PCP
Ubiquitin ligases with established roles in dictating cell polarity have been identified as components of the planar cell polarity pathway.
- Motoring Along the Immunological Synapse
Without nonmuscle myosin IIA, the immunological synapse between a T cell and an antigen-presenting cell fails to persist, interrupting T cell receptor signaling.
- Growth Cones Need p53
The tumor suppressor p53 may regulate Rho kinase to contribute to axonal growth cone motility.
- Model Progesterone Response
Interacting negative feedback loops control the sensitivity of amphibian oocytes to the hormone progesterone.
