Gαi1 and Gαi3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway

Cong Cao; Xuesong Huang; Yuyuan Han; Yinsheng Wan; Lutz Birnbaumer; Geng-Sheng Feng; John Marshall; Meisheng Jiang; Wen-Ming Chu

doi:10.1126/scisignal.2000118

Research ArticleG Proteins

Gα_i1 and Gα_i3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway

Cong Cao¹,²,
Xuesong Huang¹,
Yuyuan Han¹,
Yinsheng Wan³,
Lutz Birnbaumer⁴,
Geng-Sheng Feng⁵,
John Marshall⁶,
Meisheng Jiang⁷, and
Wen-Ming Chu¹,²,*

¹Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.
²Pathobiology Graduate Program, Brown University, Providence, RI 02912, USA.
³Department of Biology, Providence College, Providence, RI 02918, USA.
⁴Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
⁵Burnham Institute for Medical Research, La Jolla, CA 92037, USA.
⁶Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA.
⁷Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

↵*To whom correspondence should be addressed. E-mail: wen-ming_chu{at}brown.edu

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Science Signaling 28 Apr 2009:
Vol. 2, Issue 68, pp. ra17
DOI: 10.1126/scisignal.2000118

Cong Cao

1Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

2Pathobiology Graduate Program, Brown University, Providence, RI 02912, USA.

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Xuesong Huang

1Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

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Yuyuan Han

1Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

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Yinsheng Wan

3Department of Biology, Providence College, Providence, RI 02918, USA.

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Lutz Birnbaumer

4Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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Geng-Sheng Feng

5Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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John Marshall

6Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA.

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Meisheng Jiang

7Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

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Wen-Ming Chu

1Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

2Pathobiology Graduate Program, Brown University, Providence, RI 02912, USA.

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For correspondence: wen-ming_chu@brown.edu

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Is corrected by - May 11, 2010

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Gα_i1 and Gα_i3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway

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