Research ArticleNeuroscience Ligand Binding to LRP1 Transactivates Trk Receptors by a Src Family Kinase–Dependent Pathway Yang Shi1, Elisabetta Mantuano1,2, Gen Inoue2,3, W. Marie Campana2, and Steven L. Gonias1,*1Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0612, USA.2Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA.3Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8677 Japan.↵*To whom correspondence should be addressed. E-mail: sgonias{at}ucsd.edu See allHide authors and affiliations Science Signaling 28 Apr 2009:Vol. 2, Issue 68, pp. ra18DOI: 10.1126/scisignal.2000188 Yang Shi 1Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0612, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Elisabetta Mantuano 1Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0612, USA.2Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Gen Inoue 2Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA.3Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8677 Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site W. Marie Campana 2Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Steven L. Gonias 1Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0612, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: sgonias@ucsd.edu Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 2 no. 68 ra18 DOI: https://doi.org/10.1126/scisignal.2000188 PubMed: 19401592 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received December 5, 2008Accepted April 9, 2009 . Copyright & Usage: Copyright © 2009, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: April 2009 to January 2021 AbstractFullPdf Apr 20092444690 May 2009242130118 Jun 2009576143 Jul 2009352827 Aug 2009252211 Sep 2009201911 Oct 2009492412 Nov 2009522216 Dec 2009872516 Jan 2010631310 Feb 2010531713 Mar 2010301817 Apr 2010211511 May 2010762210 Jun 2010511714 Jul 2010481914 Aug 20101382214 Sep 2010591410 Oct 201053816 Nov 201037139 Dec 201025410 Jan 201132117 Feb 20112896 Mar 2011621018 Apr 201145212 May 201132513 Jun 20113447 Jul 20112669 Aug 20111738 Sep 20113168 Oct 20111904 Nov 20113157 Dec 20113485 Jan 201234812 Feb 20123387 Mar 20122945 Apr 20121676 May 20122878 Jun 201237512 Jul 20122929 Aug 20124034 Sep 20122914 Oct 20122244 Nov 20122142 Dec 20121756 Jan 20132722 Feb 20132054 Mar 20131668 Apr 20131622 May 20132277 Jun 201332134 Jul 20133787 Aug 2013381212 Sep 20132002 Oct 20134786 Nov 20133834 Dec 20134247 Jan 201438119 Feb 20142867 Mar 20143032 Apr 20142710 May 20143389 Jun 20144223 Jul 20142863 Aug 20141955 Sep 20141543 Oct 20141422 Nov 20141521 Dec 2014946 Jan 20151095 Feb 2015843 Mar 20151653 Apr 20151452 May 2015942 Jun 20152423 Jul 20151212 Aug 2015425 Sep 2015915 Oct 2015211 Nov 201502815 Dec 201512155 Jan 20165824 Feb 20163026 Mar 20163638 Apr 201637311 May 20163742 Jun 20165565 Jul 20164562 Aug 20164632 Sep 20163122 Oct 20164100 Nov 20164611 Dec 20165012 Jan 20174522 Feb 20173424 Mar 20173113 Apr 20173705 May 20173015 Jun 20172933 Jul 20174034 Aug 20174121 Sep 20173511 Oct 20172122 Nov 20173226 Dec 20171915 Jan 20183941 Feb 20182722 Mar 20183232 Apr 20183543 May 20184341 Jun 20183923 Jul 20182931 Aug 20181652 Sep 20182843 Oct 201844126 Nov 20182283 Dec 20182751 Jan 20192954 Feb 20192761 Mar 20194195 Apr 201917109 May 20192752 Jun 20193131 Jul 20191943 Aug 20191445 Sep 20192352 Oct 20192153 Nov 20191873 Dec 20193432 Jan 202040112 Feb 202027123 Mar 202019113 Apr 202018115 May 202017126 Jun 20201955 Jul 20201083 Aug 20201595 Sep 2020161012 Oct 202041101 Nov 20202654 Dec 202028139 Jan 20211054 View Full Text
Ligand Binding to LRP1 Transactivates Trk Receptors by a Src Family Kinase–Dependent Pathway By Yang Shi, Elisabetta Mantuano, Gen Inoue, W. Marie Campana, Steven L. Gonias Science Signaling28 Apr 2009 : ra18 Trk receptor–mediated neurite outgrowth is triggered by distinct ligands that activate LRP1.
Ligand Binding to LRP1 Transactivates Trk Receptors by a Src Family Kinase–Dependent Pathway By Yang Shi, Elisabetta Mantuano, Gen Inoue, W. Marie Campana, Steven L. Gonias Science Signaling28 Apr 2009 : ra18 Trk receptor–mediated neurite outgrowth is triggered by distinct ligands that activate LRP1.