Contents
Vol 2, Issue 70
Contents
Research Article
- TRPM1 Forms Ion Channels Associated with Melanin Content in Melanocytes
Newly identified TRPM1 isoforms that mediate current are highly conserved, present intracellularly, and associated with melanin content.
Perspectives
- The Quest for Long-Distance Signals in Plant Systemic Immunity
Infected plant tissues generate diffusible signals that prime defenses in the rest of the plant.
- The Yin and Yang of Synaptic Active Zone Assembly
An antagonist of two protein-protein interactions required for synapse formation has been identified in C. elegans.
Presentation
- Integrative Analysis of Genome-Wide RNA Interference Screens
By integrating RNAi screens with protein-protein interaction data, drug-protein interaction data, or disease-genotype data, researchers can focus their efforts on the best hits.
Editors' Choice
- The Skinny on Blood Pressure?
Macrophage-dependent secretion of VEGF-C stimulates the growth of lymphatic capillaries, thereby contributing to blood pressure homeostasis in the response to a high-salt diet.
- Get Busy and Get Going
The second messenger cAMP instructs the guanine nucleotide exchange factor Epac1 both to become activated and to move to the plasma membrane.
- p110β Goes Nuclear
The p110β catalytic subunit of PI3K regulates protein-protein interactions in DNA replication.
- Infections and Defense
An enzyme in tomato targets bacterial virulence to change the outcome of infection from susceptibility to immunity.
- A Second Act for Antiandrogens
A drug that binds to the androgen receptor acts by disrupting its activity in the cell nucleus.
