19 May 2009
Vol 2, Issue 71
  • Contents

    • Research Articles

    • Perspective

    • Podcast

    • Editors' Choice

      • Satiety Signal and Memory Enhancer

        The fatty acid oleoylethanolamide, which is produced in response to feeding, enhances rodent memory consolidation.

      • High on Sirtuins

        The sirtuin deacetylases are implicated in long-term changes in gene expression associated with chronic exposure to cocaine.

      • Synaptic Tag Tagged

        The protein Vesl-1S fulfills the synaptic tagging hypothesis for the maintenance of input-specific action of neuronal networks.

      • Promoting Dimerization

        EGFR autophosphorylation affects ligand-binding affinity.

      • Oocyte Support Group

        ERKs 1 and 2 are required in granulosa cells for oocyte maturation.

      • Stop-Go Axon Crossing

        A single receptor in Drosophila is involved in two molecular strategies that coordinate axon guidance.

About The Cover

Cover image expansion

COVER This week's issue features a Research Article that shows that, in addition to being found at the plasma membrane, the transient receptor potential channel TRPM2 is found in a lysosomal compartment in pancreatic β cells and mediates β cell death in response to oxidative stress. The image shows the presence of TRPM2 (green) in a rat pancreatic β cell line stained for the endoplasmic reticulum (red) and the nucleus (blue). [Image: Santiago Partida-Sanchez, The Ohio State University College of Medicine, Columbus, OH, USA]