Deciphering Signaling Outcomes from a System of Complex Networks

Robert C. Hsueh; Madhusudan Natarajan; Iain Fraser; Blake Pond; Jamie Liu; Susanne Mumby; Heping Han; Lily I. Jiang; Melvin I. Simon; Ronald Taussig; Paul C. Sternweis

doi:10.1126/scisignal.2000054

Research ArticleCell Biology

Deciphering Signaling Outcomes from a System of Complex Networks

Robert C. Hsueh¹,*,†,
Madhusudan Natarajan¹,*,‡,
Iain Fraser²,
Blake Pond¹,
Jamie Liu²,
Susanne Mumby¹,
Heping Han¹,
Lily I. Jiang¹,
Melvin I. Simon²,
Ronald Taussig¹, and
Paul C. Sternweis¹,§

¹University of Texas Southwestern Medical Center, Dallas, TX 75390–9041, USA.
²California Institute of Technology, Pasadena, CA 91125, USA.

↵§To whom correspondence should be addressed. Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390–9041, USA. E-mail: Paul.Sternweis{at}UTSouthwestern.edu

↵* These authors contributed equally to this work.
↵† Present address: Cadent Medical Communications, Irving, TX 75063, USA.
↵‡ Present address: Systems Biology Group, Pfizer Research Technology Centre, Cambridge, MA 02139, USA.

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Science Signaling 19 May 2009:
Vol. 2, Issue 71, pp. ra22
DOI: 10.1126/scisignal.2000054

Robert C. Hsueh

1University of Texas Southwestern Medical Center, Dallas, TX 75390–9041, USA.

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Madhusudan Natarajan

1University of Texas Southwestern Medical Center, Dallas, TX 75390–9041, USA.

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Iain Fraser

2California Institute of Technology, Pasadena, CA 91125, USA.

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Blake Pond

1University of Texas Southwestern Medical Center, Dallas, TX 75390–9041, USA.

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Jamie Liu

2California Institute of Technology, Pasadena, CA 91125, USA.

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Susanne Mumby

1University of Texas Southwestern Medical Center, Dallas, TX 75390–9041, USA.

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Heping Han

1University of Texas Southwestern Medical Center, Dallas, TX 75390–9041, USA.

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Lily I. Jiang

1University of Texas Southwestern Medical Center, Dallas, TX 75390–9041, USA.

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Melvin I. Simon

2California Institute of Technology, Pasadena, CA 91125, USA.

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Ronald Taussig

1University of Texas Southwestern Medical Center, Dallas, TX 75390–9041, USA.

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Paul C. Sternweis

1University of Texas Southwestern Medical Center, Dallas, TX 75390–9041, USA.

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For correspondence: Paul.Sternweis@UTSouthwestern.edu

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