26 May 2009
Vol 2, Issue 72
  • Contents

    • Editorial Guide

    • Research Articles

    • Review

    • Editors' Choice

      • Why Embryos Need a Beating Heart

        Blood flow triggers the production of nitric oxide, which is essential for the initial formation of hematopoietic stem cells during embryogenesis.

      • TGF-β Signaling Not Required

        The type III TGF-β receptor inhibits migration through β-arrestin 2 and Cdc42.

      • Inhibiting Met

        Decorin, known for inhibiting tumor growth, triggers the down-regulation of multiple receptor tyrosine kinases.

      • TLR7 Is for Bacteria, Too

        Phagosomal bacteria trigger a TLR7-dependent response in a cell type–specific manner to induce production of type I interferons.

      • Controlling Trafficking with a Ubiquitin Switch

        A monoubiquitinylation cycle appears to control the distribution of Lst2, a protein that contributes to the delivery of EGFR to lysosomes.

      • ABA Receptor Rumbled?

        Links between two ancient multimember protein families signal responses to the plant hormone abscisic acid.

      • Deadly Noise

        Variability in cellular responses to a cytokine reflects differences in protein concentration or state.

About The Cover

Cover image expansion

COVER This week's issue features a Review that describes the cell-specific responses mediated by the scavenger receptor CD36. CD36 binds diverse ligands, such as the matrix protein thrombospondin, long-chain fatty acids, and oxidized phospholipids and lipoproteins, and regulates processes such as angiogenesis, innate immune responses, fatty acid metabolism, and sensory responses to fatty acids. The image shows an artist's rendition of CD36 in the plasma membrane. [Image: Preston Huey, AAAS]