Contents
Vol 2, Issue 72
Contents
Editorial Guide
- “Omic” Risk Assessment
Integration of multiple data sets is the key to hit validation.
Research Articles
- System-Wide Changes to SUMO Modifications in Response to Heat Shock
The small ubiquitin-like modifier protein SUMO is redistributed among many targets to mediate both short- and long-term signaling events.
- Bruton’s Tyrosine Kinase Revealed as a Negative Regulator of Wnt–β-Catenin Signaling
Combining an siRNA screen with a small-molecule screen reveals BTK as a nuclear inhibitor of the Wnt–β-catenin pathway.
Review
- CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior
Signaling by CD36 is ligand and cell specific and is implicated in multiple human diseases.
Editors' Choice
- Why Embryos Need a Beating Heart
Blood flow triggers the production of nitric oxide, which is essential for the initial formation of hematopoietic stem cells during embryogenesis.
- TGF-β Signaling Not Required
The type III TGF-β receptor inhibits migration through β-arrestin 2 and Cdc42.
- Inhibiting Met
Decorin, known for inhibiting tumor growth, triggers the down-regulation of multiple receptor tyrosine kinases.
- TLR7 Is for Bacteria, Too
Phagosomal bacteria trigger a TLR7-dependent response in a cell type–specific manner to induce production of type I interferons.
- Chromatin Modifier Modulates Gene Expression
Histone acetylation and gene expression in mammals are modulated by glycolytic metabolism.
- Controlling Trafficking with a Ubiquitin Switch
A monoubiquitinylation cycle appears to control the distribution of Lst2, a protein that contributes to the delivery of EGFR to lysosomes.
- ABA Receptor Rumbled?
Links between two ancient multimember protein families signal responses to the plant hormone abscisic acid.
- Deadly Noise
Variability in cellular responses to a cytokine reflects differences in protein concentration or state.
