eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.
Research ArticleCell Biology
Bruton’s Tyrosine Kinase Revealed as a Negative Regulator of Wnt–β-Catenin Signaling
- Richard G. James1,2,*,
- Travis L. Biechele1,2,*,
- William H. Conrad1,2,
- Nathan D. Camp1,2,
- Daniel M. Fass3,†,
- Michael B. Major1,2,
- Karen Sommer4,
- XianHua Yi5,
- Brian S. Roberts6,
- Michele A. Cleary6,
- William T. Arthur6,
- Michael MacCoss5,
- David J. Rawlings4,
- Stephen J. Haggarty3,†, and
- Randall T. Moon1,2,‡
- 1Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
- 2Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
- 3The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Street, Cambridge, MA 02141, USA.
- 4Departments of Pediatrics and Immunology, Seattle Children’s Research Institute, 1900 Ninth Avenue, C9S-7, Seattle, WA 98101, USA.
- 5Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
- 6Rosetta Inpharmatics, LLC, a wholly owned subsidiary of Merck & Co Inc., 401 Terry Avenue N, Seattle, WA 98109, USA.
- ↵‡To whom correspondence should be addressed. E-mail: rtmoon{at}u.washington.edu
See allHide authors and affiliations
Science Signaling 26 May 2009:
Vol. 2, Issue 72, pp. ra25
DOI: 10.1126/scisignal.2000230
Vol. 2, Issue 72, pp. ra25
DOI: 10.1126/scisignal.2000230
Richard G. James
1Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
2Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
Travis L. Biechele
1Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
2Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
William H. Conrad
1Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
2Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
Nathan D. Camp
1Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
2Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
Daniel M. Fass
3The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Street, Cambridge, MA 02141, USA.
Michael B. Major
1Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
2Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
Karen Sommer
4Departments of Pediatrics and Immunology, Seattle Children’s Research Institute, 1900 Ninth Avenue, C9S-7, Seattle, WA 98101, USA.
XianHua Yi
5Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Brian S. Roberts
6Rosetta Inpharmatics, LLC, a wholly owned subsidiary of Merck & Co Inc., 401 Terry Avenue N, Seattle, WA 98109, USA.
Michele A. Cleary
6Rosetta Inpharmatics, LLC, a wholly owned subsidiary of Merck & Co Inc., 401 Terry Avenue N, Seattle, WA 98109, USA.
William T. Arthur
6Rosetta Inpharmatics, LLC, a wholly owned subsidiary of Merck & Co Inc., 401 Terry Avenue N, Seattle, WA 98109, USA.
Michael MacCoss
5Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
David J. Rawlings
4Departments of Pediatrics and Immunology, Seattle Children’s Research Institute, 1900 Ninth Avenue, C9S-7, Seattle, WA 98101, USA.
Stephen J. Haggarty
3The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Street, Cambridge, MA 02141, USA.
Randall T. Moon
1Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
2Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.
Submit a Response to This Article
No eLetters have been published for this article.