02 June 2009
Vol 2, Issue 73
  • Contents

    • Research Article

    • Perspective

    • Editors' Choice

      • Last Fly Standing

        Happyhour, a Ste20-like kinase that inhibits epidermal growth factor receptor signaling, increases the sedative response to ethanol.

      • Escape by Trace Amine

        The trace amine tyramine mediates fast inhibitory synaptic transmission by activating a ligand-gated chloride channel in C. elegans.

      • Signaling in Absentia

        The absence of signaling by the hormone auxin in a small group of cells is essential for seed formation in Arabidopsis.

      • Conjugate Formation

        The NKG2D-mediated cytotoxic response of natural killer cells is dependent on PI3K activity and the adaptor protein CrkL.

      • A CRAC in the Oscillatory Code?

        Even in the presence of cytoplasmic Ca2+ oscillations, influx through CRAC channels can provide a local Ca2+ signal crucial to activation of gene expression.

      • Building Biocounters

        Bacteria can be engineered to remember input signals and to respond only when a particular number has been achieved.

      • GLUT4, Clathrin, and Glucose

        A human-specific vesicle-forming protein regulates relocation of a glucose transporter to the cell membrane.

      • Anti-Aging

        Induction of the hypoxic response in a worm slows aging and enhances resistance to proteotoxicity.

      • Small but Strong

        Focal adhesion kinase pulls paxillin from nudel to allow maturation of focal contacts.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective about the allosteric regulation of glucocorticoid receptor activity by DNA. The image (based on PDB 1r4r) shows the crystal structure of the glucocorticoid receptor (orange and red) bound to DNA. [Image: Christopher Bickel, AAAS]