Contents

Contents

• Research Article

  • Involvement of the Protein Kinase CK2 in the Regulation of Mammalian Circadian Rhythms

    By Yoshiki Tsuchiya, Makoto Akashi, Mitsuhiro Matsuda, Kyoko Goto, Yoshihiko Miyata, Koichi Node, Eisuke Nishida

    Science Signaling02 Jun 2009 : ra26 Full AccessRestricted Access

    Protein kinase CK2 promotes PERIOD2 degradation and modulates the mammalian circadian clock.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspective

  • Allosteric Effects Govern Nuclear Receptor Action: DNA Appears as a Player

    By Hinrich Gronemeyer, William Bourguet

    Science Signaling02 Jun 2009 : pe34 Full AccessRestricted Access

    DNA sequences regulate glucocorticoid receptor activity.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Last Fly Standing

    By Nancy R. Gough

    Science Signaling02 Jun 2009 : ec179 Full AccessRestricted Access

    Happyhour, a Ste20-like kinase that inhibits epidermal growth factor receptor signaling, increases the sedative response to ethanol.

    • Abstract

  • Escape by Trace Amine

    By Wei Wong

    Science Signaling02 Jun 2009 : ec180 Full AccessRestricted Access

    The trace amine tyramine mediates fast inhibitory synaptic transmission by activating a ligand-gated chloride channel in C. elegans.

    • Abstract

  • Signaling in Absentia

    By L. Bryan Ray

    Science Signaling02 Jun 2009 : ec181 Full AccessRestricted Access

    The absence of signaling by the hormone auxin in a small group of cells is essential for seed formation in Arabidopsis.

    • Abstract

  • Conjugate Formation

    By John F. Foley

    Science Signaling02 Jun 2009 : ec182 Full AccessRestricted Access

    The NKG2D-mediated cytotoxic response of natural killer cells is dependent on PI3K activity and the adaptor protein CrkL.

    • Abstract

  • A CRAC in the Oscillatory Code?

    By Elizabeth M. Adler

    Science Signaling02 Jun 2009 : ec183 Full AccessRestricted Access

    Even in the presence of cytoplasmic Ca²⁺ oscillations, influx through CRAC channels can provide a local Ca²⁺ signal crucial to activation of gene expression.

    • Abstract

  • Building Biocounters

    By Nancy R. Gough

    Science Signaling02 Jun 2009 : ec184 Full AccessRestricted Access

    Bacteria can be engineered to remember input signals and to respond only when a particular number has been achieved.

    • Abstract

  • GLUT4, Clathrin, and Glucose

    By Stella Hurtley

    Science Signaling02 Jun 2009 : ec185 Full AccessRestricted Access

    A human-specific vesicle-forming protein regulates relocation of a glucose transporter to the cell membrane.

    • Abstract

  • Anti-Aging

    By Helen Pickersgill

    Science Signaling02 Jun 2009 : ec186 Full AccessRestricted Access

    Induction of the hypoxic response in a worm slows aging and enhances resistance to proteotoxicity.

    • Abstract

  • Small but Strong

    By Nancy R. Gough

    Science Signaling02 Jun 2009 : ec187 Full AccessRestricted Access

    Focal adhesion kinase pulls paxillin from nudel to allow maturation of focal contacts.

    • Abstract