Contents
Vol 2, Issue 73
Contents
Research Article
- Involvement of the Protein Kinase CK2 in the Regulation of Mammalian Circadian Rhythms
Protein kinase CK2 promotes PERIOD2 degradation and modulates the mammalian circadian clock.
Perspective
- Allosteric Effects Govern Nuclear Receptor Action: DNA Appears as a Player
DNA sequences regulate glucocorticoid receptor activity.
Editors' Choice
- Last Fly Standing
Happyhour, a Ste20-like kinase that inhibits epidermal growth factor receptor signaling, increases the sedative response to ethanol.
- Escape by Trace Amine
The trace amine tyramine mediates fast inhibitory synaptic transmission by activating a ligand-gated chloride channel in C. elegans.
- Signaling in Absentia
The absence of signaling by the hormone auxin in a small group of cells is essential for seed formation in Arabidopsis.
- Conjugate Formation
The NKG2D-mediated cytotoxic response of natural killer cells is dependent on PI3K activity and the adaptor protein CrkL.
- A CRAC in the Oscillatory Code?
Even in the presence of cytoplasmic Ca2+ oscillations, influx through CRAC channels can provide a local Ca2+ signal crucial to activation of gene expression.
- Building Biocounters
Bacteria can be engineered to remember input signals and to respond only when a particular number has been achieved.
- GLUT4, Clathrin, and Glucose
A human-specific vesicle-forming protein regulates relocation of a glucose transporter to the cell membrane.
- Anti-Aging
Induction of the hypoxic response in a worm slows aging and enhances resistance to proteotoxicity.
- Small but Strong
Focal adhesion kinase pulls paxillin from nudel to allow maturation of focal contacts.
