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Tuning the Mammalian Beat
Many physiological and behavioral processes wax and wane during the course of the day. These circadian cycles depend on interlocking transcriptional and translational feedback loops. Phosphorylation of the clock protein PERIOD2 (PER2) regulates its degradation and subcellular localization, thereby playing a critical role in determining rhythm length and strength. Tsuchiya et al. now show that the protein kinase CK2 binds to and phosphorylates PER2, cooperating with the protein kinase CKIε to promote PER2 degradation and thereby contributing to regulation of both the amplitude and period of the mammalian circadian clock.
