09 June 2009
Vol 2, Issue 74
  • Contents

    • Research Article

    • Perspectives

    • Podcast

    • Editors' Choice

      • Catching Your Breath

        Nicotine attenuates the response of neonatal adrenal chromaffin cells to hypoxia by increasing the abundance of KATP channels.

      • Cancer Is Depressing

        Rats with peripheral tumors exhibit depressive- and anxiety-like behaviors, which may be due to proinflammatory cytokines and reduced corticosterone.

      • Beatnik Kinase

        The kinase CTR1 locally suppresses auxin biosynthesis, contributing to a concentration gradient that regulates planar polarity in Arabidopsis root tips.

      • Coordinating Response to Stress

        A deacetylase implicated in aging directly regulates a transcription factor that controls stress-responsive genes.

      • Starving T Cells

        Activation of the amino acid starvation response inhibits differentiation of a subset of inflammatory T cells.

      • Rheb Permits Aggresome Formation

        Rheb has an mTOR-independent role in controlling cellular responses to misfolded proteins.

      • Transcriptional Repressor Dissected

        A protein kinase can specifically target arginine residues in a transcription factor to regulate its DNA binding.

      • Rhes-olving Huntington’s Disease?

        A small G protein localized in the striatum may explain the localized neurodegeneration observed in Huntington’s disease.

      • Signaling Activity in Vivo

        FRET analysis reveals temporal and spatial patterns of Cdc42 activation in individual cells and the whole fly embryo.

      • Thinking Thin with Mom’s Gα Gene

        Brain expression of the maternal allele encoding the G protein αs subunit is essential for proper metabolic regulation.

About The Cover

Cover image expansion

COVER This week's issue features a Research Article that describes how the responses of mast cells to activation of phosphoinositide 3-kinase (PI3K) depend on the identity of the adaptor subunit that makes up the PI3K complex. Listen to an interview with Matthias Wymann, senior author of the Research Article, in this week's Podcast. The image shows an artist's depiction of a degranulating mast cell. [Image: Christopher Bickel, AAAS]