Contents
Vol 2, Issue 76
Contents
Research Articles
- The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling
Kif7 may be the functional equivalent of the Drosophila kinesin-like protein Costal2.
- PKC-θ Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation
PKC-θ triggers the degradation of Cbl-b that is necessary for a full immune response in T cells.
Perspective
- Activation of T Cells: Releasing the Brakes by Proteolytic Elimination of Cbl-b
Degradation of the ubiquitin E3 ligase Cbl-b in response to T cell costimulation depends on PKC-θ.
Podcast
- Science Signaling Podcast: 23 June 2009
A microfluidic device enables high-throughput analysis of signaling in individual cells.
Editors' Choice
- No Phosphate, No Problem
CD44-dependent proliferation of gastric cancer cells is mediated by acetylated, but unphosphorylated, STAT3.
- Not Just a Translator
The ERK pathway promotes phosphorylation of lysyl-tRNA synthetase and its nuclear translocation during mast cell activation.
- Limiting Brain Access
The CCR7 chemokine receptor is critical for invasion of the central nervous system by T cell acute lymphoblastic leukemia cells.
- Kinetic Control of NF-κB
Complex formation, protein processing, and biosynthesis contribute to the rapid and long-term responses to stimuli that activate NF-κB.
- Sensorin Reporter
Live-cell microscopy reveals local translation during long-term facilitation of Aplysia sensory-motor synapses.
- Getting to the Scene
H2O2 represents a critical signal for recruiting leukocytes to injury sites.
- Controlling Chronic Viral Infections
The cytokine interleukin-21 has a profound impact on virus-specific T cell responses to chronic infections in mice.
- Antiporter Antics
The architecture of a membrane protein channel helps explain how Escherichia coli survive the acidic conditions of the stomach.
