Contents
Vol 2, Issue 77
Contents
Editorial Guide
- Challenging Times
The deluge of NIH “challenge grants” promises to strain the reviewer pool.
Research Articles
- Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor–PI3K Axis
Computational modeling of the ErbB signaling network affirms ErbB3 as a therapeutic target.
- PKCɛ Regulation of an α5 Integrin–ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells
Phosphorylated ZO-1 relocalizes from tight junctions to lamellae to associate with α5 integrin and control migration.
Perspective
- AIMing 2 Detect Foreign DNA
AIM2 is a receptor for cytoplasmic double-stranded DNA and induces the formation of an IL-1β–secreting inflammasome.
Podcast
- Science Signaling Podcast: 30 June 2009
Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies.
Editors' Choice
- Really Random Receptors
Observations of single receptor molecules show that random membrane insertion can account for highly organized clusters of receptors in bacteria.
- ERADicating Cadmium
Yeast sense the environmental toxin cadmium at the endoplasmic reticulum to prevent the degradation of the toxin's transporter.
- Ras, STAT3, and Transformation
A transcription factor promotes the transformation of cells by the Ras oncogene only when present in the mitochondrion.
- Endogenous Angiogenesis Inhibition
Inhibition of angiogenesis by DSCR1 through the VEGF-calcineurin pathway may contribute to decreased incidence of tumors in Down syndrome.
- Of Life, Limb, and a Small RNA
Inhibition of a microRNA that represses blood vessel growth enhances the recovery of tissue damaged by an inadequate blood supply.
- Touch of Life
Dendritic cells that form an immune synapse with T cells receive a prosurvival signal.
- Ubiquitination Counters Inflammation
Nrdp1 ubiquitinates two proteins involved in Toll-like receptor signaling to promote production of anti-inflammatory over proinflammatory cytokines.
- Patched Gets a GRK
Hedgehog promotes the interaction of G protein–coupled receptor kinase with Patched, releasing cyclin B1 to stimulate cell proliferation.
- Pathways to Induction
Cell fate specification in the pancreas and liver are coordinated by a precise temporal order of specific sets of signals.
- BDNF and Drug Dependence
A growth factor involved in neuronal plasticity alters neurons in a specific area of the brain after chronic exposure to opioid drugs.
- Flower Functionalization
An auxin gradient is involved in cell fate specification of the female sex cells in flowering plants.
