30 June 2009
Vol 2, Issue 77
  • Contents

    • Editorial Guide

      • Challenging Times

        The deluge of NIH “challenge grants” promises to strain the reviewer pool.

    • Research Articles

    • Perspective

      • AIMing 2 Detect Foreign DNA

        AIM2 is a receptor for cytoplasmic double-stranded DNA and induces the formation of an IL-1β–secreting inflammasome.

    • Podcast

    • Editors' Choice

      • Really Random Receptors

        Observations of single receptor molecules show that random membrane insertion can account for highly organized clusters of receptors in bacteria.

      • ERADicating Cadmium

        Yeast sense the environmental toxin cadmium at the endoplasmic reticulum to prevent the degradation of the toxin's transporter.

      • Ras, STAT3, and Transformation

        A transcription factor promotes the transformation of cells by the Ras oncogene only when present in the mitochondrion.

      • Endogenous Angiogenesis Inhibition

        Inhibition of angiogenesis by DSCR1 through the VEGF-calcineurin pathway may contribute to decreased incidence of tumors in Down syndrome.

      • Of Life, Limb, and a Small RNA

        Inhibition of a microRNA that represses blood vessel growth enhances the recovery of tissue damaged by an inadequate blood supply.

      • Touch of Life

        Dendritic cells that form an immune synapse with T cells receive a prosurvival signal.

      • Ubiquitination Counters Inflammation

        Nrdp1 ubiquitinates two proteins involved in Toll-like receptor signaling to promote production of anti-inflammatory over proinflammatory cytokines.

      • Patched Gets a GRK

        Hedgehog promotes the interaction of G protein–coupled receptor kinase with Patched, releasing cyclin B1 to stimulate cell proliferation.

      • Pathways to Induction

        Cell fate specification in the pancreas and liver are coordinated by a precise temporal order of specific sets of signals.

      • BDNF and Drug Dependence

        A growth factor involved in neuronal plasticity alters neurons in a specific area of the brain after chronic exposure to opioid drugs.

      • Flower Functionalization

        An auxin gradient is involved in cell fate specification of the female sex cells in flowering plants.

About The Cover

Cover image expansion

COVER This week's issue features a Research Article that describes how PKCε regulates the phosphorylation of the tight junction protein zonula occludens-1 (ZO-1), triggering its relocalization to the leading edge of subconfluent cells, where it interacts with α5 integrin to promote lamellae formation and migration. The image shows that α5 integrin (red) and ZO-1 (green) colocalize in the lamellae of a lung cancer cell line. [Image: Saara Tuomi, University of Turku and VTT Technical Research Centre of Finland]