Contents
Vol 2, Issue 78
Contents
Research Article
- Oxygen-Regulated β2-Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL
Hypoxia reduces proline hydroxylation and ubiquitylation of a G protein–coupled receptor, preventing down-regulation.
Perspective
- Caspase-8 for Outer Harmony
Ablation of caspase-8 in keratinocytes activates proliferative and inflammatory responses in the epidermis.
Editors' Choice
- Different Scaffold, Add Calcium
KSR2 interacts with the calcium-activated phosphatase calcineurin, thereby coupling calcium and ERK signaling.
- Fat and Susceptible to Infection
Free fatty acids trigger the production of an inhibitor of Akt in macrophages, which contributes to the susceptibility to infection associated with diet-induced obesity.
- Making Immunological Memories
Manipulation of cellular metabolic pathways influences memory T cell generation.
- Switching Roles
Signaling by type I interferon (IFN) switches PLZF from being a transcriptional repressor to an activator required for the expression of a subset of IFN-stimulated genes.
- Modifying the Modifier
An oxygenase with an important role in vertebrate development hydroxylates a messenger RNA-splicing factor.
- The Bacterial Version of Photoshop
A population of bacteria is engineered to communicate with each other and to detect differences in illumination to define light-dark edges.
- Breaking the Barrier
Adhesion of bacteria to cells lining blood vessels in the brain induces them to part and allows pathogen invasion.
- JNK Slowdown
The mutant Huntingtin protein inhibits fast axonal transport by activating a JNK isoform that is enriched in brain.
- Biogenic Amine Receptors
An expanded family of receptor channels that binds neurotransmitters in worms might help explain behavioral effects in humans.
- Idolizing Cholesterol Control
Cholesterol metabolism is regulated by a signaling pathway that targets the low density lipoprotein receptor for degradation.
