07 July 2009
Vol 2, Issue 78
  • Contents

    • Research Article

    • Perspective

      • Caspase-8 for Outer Harmony

        Ablation of caspase-8 in keratinocytes activates proliferative and inflammatory responses in the epidermis.

    • Editors' Choice

      • Different Scaffold, Add Calcium

        KSR2 interacts with the calcium-activated phosphatase calcineurin, thereby coupling calcium and ERK signaling.

      • Fat and Susceptible to Infection

        Free fatty acids trigger the production of an inhibitor of Akt in macrophages, which contributes to the susceptibility to infection associated with diet-induced obesity.

      • Making Immunological Memories

        Manipulation of cellular metabolic pathways influences memory T cell generation.

      • Switching Roles

        Signaling by type I interferon (IFN) switches PLZF from being a transcriptional repressor to an activator required for the expression of a subset of IFN-stimulated genes.

      • Modifying the Modifier

        An oxygenase with an important role in vertebrate development hydroxylates a messenger RNA-splicing factor.

      • The Bacterial Version of Photoshop

        A population of bacteria is engineered to communicate with each other and to detect differences in illumination to define light-dark edges.

      • Breaking the Barrier

        Adhesion of bacteria to cells lining blood vessels in the brain induces them to part and allows pathogen invasion.

      • JNK Slowdown

        The mutant Huntingtin protein inhibits fast axonal transport by activating a JNK isoform that is enriched in brain.

      • Biogenic Amine Receptors

        An expanded family of receptor channels that binds neurotransmitters in worms might help explain behavioral effects in humans.

      • Idolizing Cholesterol Control

        Cholesterol metabolism is regulated by a signaling pathway that targets the low density lipoprotein receptor for degradation.

About The Cover

Cover image expansion

COVER This week's issue features a Perspective that describes how loss of caspase-8 in keratinocytes causes hyperproliferative and inflammatory responses in the epidermis. The image is an artist's rendition of immune cells infiltrating the epidermis because of an inflammatory stimulus. [Image: Preston Huey, AAAS]