Contents

Contents

• Research Article

  • Control of Neuronal Growth Cone Navigation by Asymmetric Inositol 1,4,5-Trisphosphate Signals

    By Hiroki Akiyama, Toru Matsu-ura, Katsuhiko Mikoshiba, Hiroyuki Kamiguchi

    Science Signaling14 Jul 2009 : ra34 Full AccessRestricted Access

    Measurements of its spatial profile reveal the crucial role of asymmetric IP₃ signals in growth cone navigation.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspective

  • Down-Regulating Destruction: Phosphorylation Regulates the E3 Ubiquitin Ligase Nedd4-2

    By Peter M. Snyder

    Science Signaling14 Jul 2009 : pe41 Full AccessRestricted Access

    Phosphorylation of Nedd4-2 regulates epithelial Na⁺ transport.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • A Calming Touch

    By John F. Foley

    Science Signaling14 Jul 2009 : ec233 Full AccessRestricted Access

    T cells inhibit inflammasome-mediated proinflammatory responses in macrophages in a cell contact–dependent manner.

    • Abstract

  • Instruction, Not Selection

    By Annalisa M. VanHook

    Science Signaling14 Jul 2009 : ec234 Full AccessRestricted Access

    Cytokines can act as instructive cues in hematopoiesis.

    • Abstract

  • ERK Breaks Up Ménage à Trois at the Plasma Membrane

    By L. Bryan Ray

    Science Signaling14 Jul 2009 : ec235 Full AccessRestricted Access

    Activation of the mitogen-activated protein kinase ERK initiates feedback phosphorylation that disrupts the complex its own activating enzymes form with a scaffold protein.

    • Abstract

  • EGFL7: An Anti-Notch Ligand

    By Nancy R. Gough

    Science Signaling14 Jul 2009 : ec236 Full AccessRestricted Access

    Epidermal growth factor–like domain 7 (EGFL7) competes with ligands for Notch and prevents Notch activation.

    • Abstract

  • Mediating Metastasis

    By Elizabeth M. Adler

    Science Signaling14 Jul 2009 : ec237 Full AccessRestricted Access

    Activation of the WNT/TCF signaling pathway is associated with brain and bone metastasis in lung adenocarcinoma.

    • Abstract

  • The Importance of Size

    By Annalisa M. VanHook

    Science Signaling14 Jul 2009 : ec238 Full AccessRestricted Access

    Growth rate is determined by cell size in lymphoblasts.

    • Abstract

  • Let Me Present to You

    By Stella Hurtley

    Science Signaling14 Jul 2009 : ec239 Full AccessRestricted Access

    Immunological dendritic cells contain an endocytic compartment involved in the cross-presentation of internalized antigens.

    • Abstract

  • Paradoxical Pain After Opioid Withdrawal

    By Peter Stern

    Science Signaling14 Jul 2009 : ec240 Full AccessRestricted Access

    Withdrawal from opioids in rats induces an increase in synaptic strength in pain pathways and thereby enhances pain sensitivity.

    • Abstract