Contents
Vol 2, Issue 79
Contents
Research Article
- Control of Neuronal Growth Cone Navigation by Asymmetric Inositol 1,4,5-Trisphosphate Signals
Measurements of its spatial profile reveal the crucial role of asymmetric IP3 signals in growth cone navigation.
Perspective
- Down-Regulating Destruction: Phosphorylation Regulates the E3 Ubiquitin Ligase Nedd4-2
Phosphorylation of Nedd4-2 regulates epithelial Na+ transport.
Editors' Choice
- A Calming Touch
T cells inhibit inflammasome-mediated proinflammatory responses in macrophages in a cell contact–dependent manner.
- ERK Breaks Up Ménage à Trois at the Plasma Membrane
Activation of the mitogen-activated protein kinase ERK initiates feedback phosphorylation that disrupts the complex its own activating enzymes form with a scaffold protein.
- EGFL7: An Anti-Notch Ligand
Epidermal growth factor–like domain 7 (EGFL7) competes with ligands for Notch and prevents Notch activation.
- Mediating Metastasis
Activation of the WNT/TCF signaling pathway is associated with brain and bone metastasis in lung adenocarcinoma.
- Let Me Present to You
Immunological dendritic cells contain an endocytic compartment involved in the cross-presentation of internalized antigens.
- Paradoxical Pain After Opioid Withdrawal
Withdrawal from opioids in rats induces an increase in synaptic strength in pain pathways and thereby enhances pain sensitivity.