Research ArticleNeuroscience Inhibition of mTOR Signaling in Parkinson’s Disease Prevents l-DOPA–Induced Dyskinesia Emanuela Santini1, Myriam Heiman2, Paul Greengard2, Emmanuel Valjent1,3,4,5, and Gilberto Fisone1,2,*1Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77 Stockholm, Sweden.2Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA.3INSERM, UMR-S839, 75005 Paris, France.4Université Pierre et Marie Curie, 75005 Paris, France.5Institut du Fer à Moulin, 75005 Paris, France.↵*To whom correspondence should be addressed. E-mail: gilberto.fisone{at}ki.se See allHide authors and affiliations Science Signaling 21 Jul 2009:Vol. 2, Issue 80, pp. ra36DOI: 10.1126/scisignal.2000308 Emanuela Santini 1Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77 Stockholm, Sweden.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Myriam Heiman 2Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Paul Greengard 2Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Emmanuel Valjent 1Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77 Stockholm, Sweden.3INSERM, UMR-S839, 75005 Paris, France.4Université Pierre et Marie Curie, 75005 Paris, France.5Institut du Fer à Moulin, 75005 Paris, France.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Gilberto Fisone 1Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77 Stockholm, Sweden.2Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: gilberto.fisone@ki.se Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 2 no. 80 ra36 DOI: https://doi.org/10.1126/scisignal.2000308 PubMed: 19622833 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received March 6, 2009Accepted July 1, 2009 . Copyright & Usage: Copyright © 2009, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: July 2009 to April 2021 AbstractFullPdf Jul 20091741231295 Aug 2009314109132 Sep 20091398064 Oct 20091005046 Nov 20091005839 Dec 20091222626 Jan 20101383938 Feb 2010733325 Mar 2010703622 Apr 2010763722 May 2010873721 Jun 2010993825 Jul 2010741612 Aug 20101342233 Sep 2010961222 Oct 2010872614 Nov 2010951319 Dec 2010631515 Jan 2011931644 Feb 2011992822 Mar 2011782723 Apr 201148919 May 2011762523 Jun 2011691816 Jul 201146148 Aug 201148911 Sep 2011951513 Oct 2011821623 Nov 2011931034 Dec 2011471612 Jan 20121032631 Feb 2012992443 Mar 2012841628 Apr 2012631514 May 2012781426 Jun 2012611016 Jul 20127467 Aug 2012751012 Sep 2012681415 Oct 201269815 Nov 2012571517 Dec 2012511311 Jan 2013532121 Feb 2013572223 Mar 2013303722 Apr 2013531512 May 2013522723 Jun 2013522119 Jul 20134485 Aug 201343167 Sep 2013542123 Oct 2013545338 Nov 2013742519 Dec 201356138 Jan 2014582324 Feb 201463238 Mar 2014722314 Apr 2014552822 May 20147198 Jun 20145488 Jul 20147154 Aug 2014181210 Sep 201460216 Oct 2014492711 Nov 2014901924 Dec 201441914 Jan 20154785 Feb 20151866 Mar 2015712015 Apr 2015521010 May 20154959 Jun 2015621110 Jul 20156255 Aug 20151169 Sep 2015511411 Oct 2015104019 Nov 2015765 Dec 20152024 Jan 201673412 Feb 20166844 Mar 2016104812 Apr 20167767 May 201678312 Jun 201611542 Jul 20168697 Aug 20167288 Sep 201677717 Oct 20166868 Nov 2016811521 Dec 20166734 Jan 20176555 Feb 20177839 Mar 201798611 Apr 201766210 May 20176657 Jun 20176326 Jul 20177747 Aug 20176651 Sep 201775411 Oct 20175233 Nov 2017851918 Dec 20174353 Jan 20184441 Feb 2018661211 Mar 201878157 Apr 2018851012 May 20188659 Jun 201869610 Jul 20185397 Aug 201830154 Sep 201840127 Oct 2018581713 Nov 201877115 Dec 20183387 Jan 201943128 Feb 20194651 Mar 201935153 Apr 20194275 May 20194086 Jun 201943813 Jul 20193578 Aug 20193294 Sep 201924105 Oct 201946159 Nov 201924278 Dec 20195261 Jan 2020411911 Feb 2020431312 Mar 202049114 Apr 202033216 May 202075198 Jun 2020331813 Jul 202030172 Aug 202016202 Sep 2020191213 Oct 202049185 Nov 202037116 Dec 2020362822 Jan 202126182 Feb 20214163 Mar 202195141 Apr 20211976 View Full Text
Inhibition of mTOR Signaling in Parkinson’s Disease Prevents l-DOPA–Induced Dyskinesia By Emanuela Santini, Myriam Heiman, Paul Greengard, Emmanuel Valjent, Gilberto Fisone Science Signaling21 Jul 2009 : ra36 Dyskinetic side effects of a Parkinson’s disease medication may involve dopamine D1 receptor–mediated activation of mTORC1.
Inhibition of mTOR Signaling in Parkinson’s Disease Prevents l-DOPA–Induced Dyskinesia By Emanuela Santini, Myriam Heiman, Paul Greengard, Emmanuel Valjent, Gilberto Fisone Science Signaling21 Jul 2009 : ra36 Dyskinetic side effects of a Parkinson’s disease medication may involve dopamine D1 receptor–mediated activation of mTORC1.