Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases

Chris Soon Heng Tan; Bernd Bodenmiller; Adrian Pasculescu; Marko Jovanovic; Michael O. Hengartner; Claus Jørgensen; Gary D. Bader; Ruedi Aebersold; Tony Pawson; Rune Linding

doi:10.1126/scisignal.2000316

Research ArticleCOMPUTATIONAL BIOLOGY

Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases

Chris Soon Heng Tan¹,²,*,
Bernd Bodenmiller³,*,
Adrian Pasculescu¹,
Marko Jovanovic⁴,
Michael O. Hengartner⁴,
Claus Jørgensen¹,
Gary D. Bader¹,²,
Ruedi Aebersold³,⁵,⁶,⁷,
Tony Pawson¹,², and
Rune Linding⁸,†

¹Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
²Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
³Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule (ETH), 8093 Zurich, Switzerland.
⁴Institute of Molecular Biology, University of Zurich, 8057 Zurich, Switzerland.
⁵Institute for Systems Biology, Seattle, WA 98103, USA.
⁶Competence Center for Systems Physiology and Metabolic Diseases, ETH Zurich, 8093 Zurich, Switzerland.
⁷Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.
⁸Cellular & Molecular Logic Team, Section of Cell and Molecular Biology, The Institute of Cancer Research (ICR), London SW3 6JB, UK.

↵†To whom correspondence should be addressed. E-mail: linding{at}icr.ac.uk

↵* These authors contributed equally to this work.

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Science Signaling 28 Jul 2009:
Vol. 2, Issue 81, pp. ra39
DOI: 10.1126/scisignal.2000316

Chris Soon Heng Tan

1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

2Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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Bernd Bodenmiller

3Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule (ETH), 8093 Zurich, Switzerland.

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Adrian Pasculescu

1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

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Marko Jovanovic

4Institute of Molecular Biology, University of Zurich, 8057 Zurich, Switzerland.

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Michael O. Hengartner

4Institute of Molecular Biology, University of Zurich, 8057 Zurich, Switzerland.

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Claus Jørgensen

1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

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Gary D. Bader

1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

2Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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Ruedi Aebersold

3Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule (ETH), 8093 Zurich, Switzerland.

5Institute for Systems Biology, Seattle, WA 98103, USA.

6Competence Center for Systems Physiology and Metabolic Diseases, ETH Zurich, 8093 Zurich, Switzerland.

7Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.

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Tony Pawson

1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

2Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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Rune Linding

8Cellular & Molecular Logic Team, Section of Cell and Molecular Biology, The Institute of Cancer Research (ICR), London SW3 6JB, UK.

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For correspondence: linding@icr.ac.uk

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Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases

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