The Akt1-eNOS Axis Illustrates the Specificity of Kinase-Substrate Relationships in Vivo

Michael Schleicher; Jun Yu; Takahisa Murata; Berhad Derakhshan; Dimitriy Atochin; Li Qian; Satoshi Kashiwagi; Annarita Di Lorenzo; Kenneth D. Harrison; Paul L. Huang; William C. Sessa

doi:10.1126/scisignal.2000343

Research ArticleAngiogenesis

The Akt1-eNOS Axis Illustrates the Specificity of Kinase-Substrate Relationships in Vivo

Michael Schleicher¹,
Jun Yu¹,
Takahisa Murata²,
Berhad Derakhshan¹,
Dimitriy Atochin³,
Li Qian³,
Satoshi Kashiwagi³,
Annarita Di Lorenzo¹,
Kenneth D. Harrison¹,
Paul L. Huang³,*, and
William C. Sessa¹,*

¹Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.
²Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
³Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA.

↵*To whom correspondence should be addressed. E-mail: huangp{at}helix.mgh.harvard.edu (P.L.H.) and william.sessa{at}yale.edu (W.C.S.)

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Science Signaling 04 Aug 2009:
Vol. 2, Issue 82, pp. ra41
DOI: 10.1126/scisignal.2000343

Michael Schleicher

Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

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Jun Yu

Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

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Takahisa Murata

Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

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Berhad Derakhshan

Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

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Dimitriy Atochin

Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA.

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Li Qian

Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA.

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Satoshi Kashiwagi

Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA.

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Annarita Di Lorenzo

Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

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Kenneth D. Harrison

Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

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Paul L. Huang

Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA.

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For correspondence: huangp@helix.mgh.harvard.edu william.sessa@yale.edu

William C. Sessa

Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

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For correspondence: huangp@helix.mgh.harvard.edu william.sessa@yale.edu

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The Akt1-eNOS Axis Illustrates the Specificity of Kinase-Substrate Relationships in Vivo

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