The Akt1-eNOS Axis Illustrates the Specificity of Kinase-Substrate Relationships in Vivo

Michael Schleicher; Jun Yu; Takahisa Murata; Berhad Derakhshan; Dimitriy Atochin; Li Qian; Satoshi Kashiwagi; Annarita Di Lorenzo; Kenneth D. Harrison; Paul L. Huang; William C. Sessa

doi:10.1126/scisignal.2000343

Research ArticleAngiogenesis

The Akt1-eNOS Axis Illustrates the Specificity of Kinase-Substrate Relationships in Vivo

Michael Schleicher¹,
Jun Yu¹,
Takahisa Murata²,
Berhad Derakhshan¹,
Dimitriy Atochin³,
Li Qian³,
Satoshi Kashiwagi³,
Annarita Di Lorenzo¹,
Kenneth D. Harrison¹,
Paul L. Huang³,*, and
William C. Sessa¹,*

¹Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.
²Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
³Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA.

↵*To whom correspondence should be addressed. E-mail: huangp{at}helix.mgh.harvard.edu (P.L.H.) and william.sessa{at}yale.edu (W.C.S.)

See allHide authors and affiliations

Science Signaling 04 Aug 2009:
Vol. 2, Issue 82, pp. ra41
DOI: 10.1126/scisignal.2000343

Michael Schleicher

1Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jun Yu

1Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Takahisa Murata

2Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Berhad Derakhshan

1Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Dimitriy Atochin

3Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Li Qian

3Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Satoshi Kashiwagi

3Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Annarita Di Lorenzo

1Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kenneth D. Harrison

1Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Paul L. Huang

3Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: huangp@helix.mgh.harvard.edu william.sessa@yale.edu

William C. Sessa

1Department of Pharmacology and Vascular Biology and Therapeutics Program, Amistad Building, Yale University School of Medicine, New Haven, CT 06520, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: huangp@helix.mgh.harvard.edu william.sessa@yale.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

The Akt1-eNOS Axis Illustrates the Specificity of Kinase-Substrate Relationships in Vivo

Plain text

Vertical Tabs

Science Signaling

Article Tools