Contents
Vol 2, Issue 83
Contents
Research Articles
- Neuronal and Intestinal Protein Kinase D Isoforms Mediate Na+ (Salt Taste)–Induced Learning
Protein kinase D signaling in the intestine and nervous system enables worms to learn to avoid salt.
- Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3ɛ
A mutant CD3ɛ subunit that cannot change conformation in response to ligand binding exerts dominant-negative inhibition of T cell responses.
Perspectives
- Actin and Microtubule-Based Cytoskeletal Cues Direct Polarized Targeting of Proteins in Neurons
Delivery of proteins to axons or dendrites depends on interactions between molecular motors and the cytoskeleton.
- New Complexity in Differentiating Stem Cells Toward Hepatic and Pancreatic Fates
Programming of the liver and pancreas is controlled by a dynamic, temporally coordinated signaling network.
Editors' Choice
- A heartless Switch in Signaling
FGF ligands released from different cell types trigger distinct glial behaviors through the same receptor.
- ATM and Inflammation
The kinase ATM, which is involved in the DNA damage response, is required for the secretion of certain inflammatory factors, such as IL-6, by senescent cells.
- Enzyme-Linked Signaling
Activation of biliverdin reductase activates anti-inflammatory signaling through phosphatidylinositol 3-kinase and Akt.
- Jamming Protein Translocation
Antibiotics promote the destruction of a vital protein translocation complex in bacteria.
- Terminal Tension?
Mechanical tension may promote accumulation of synaptic vesicles in developing synapses.
- Plastic Pain Perception
Noxious stimulation releases endocannabinoids in the spinal cord that may promote, rather than inhibit, the perception of pain.
- Fine Dendrites Fire Differently
Thin tuft and basal dendrites of pyramidal neurons use N-methyl-d-aspartate spikes to sum up synaptic inputs in semi-independent compartments.
Erratum
