Contents
Vol 2, Issue 85
Contents
Editorial Guide
- Re-reviewing Peer Review
Constructive criticism is the key to effective peer review.
Research Article
- The VDAC2-BAK Rheostat Controls Thymocyte Survival
The relative abundance of an anion channel and a proapoptotic protein determines thymocyte responses to death signals.
Perspectives
- Controlling the Number of Tooth Rows
Bmp4 distribution in the mouse jaw is restricted to prevent the induction of supernumerary teeth.
- Epac2: A Molecular Target for Sulfonylurea-Induced Insulin Release
Epac2 is an intracellular receptor for a commonly used class of antidiabetic medications.
Presentation
- The Mechanotransduction Machinery of Hair Cells
Studying genes linked to deafness identifies components of the ear's mechanotransduction apparatus.
Teaching Resource
- Training for Peer Review
Graduate students and postdocs may benefit from formal training in peer reviewing.
Editors' Choice
- When a Better Immune Response Is Bad
Increased signaling of plasmacytoid dendritic cells through TLR7 and TLR8, triggered by HIV-1–derived ligands, underlies women’s increased susceptibility to progression to AIDs.
- Signals from a Sunken Ship
The G protein–coupled receptor for thyroid-stimulating hormone continues to couple to adenylyl cyclase and generate cyclic AMP after it is internalized.
- When Repair Is Suicide
Persistent elevated calcium in apoptotic cells triggers fusion of lysosomes with the plasma membrane, producing the membrane-associated hallmarks of programmed cell death.
- Minimizing Plasticity
Modulation of calcium buffering and extrusion may provide a mechanism for regulating long-term potentiation.
- Making Memories Last
Pharmacological and biochemical analyses reveal that dopamine determines the duration of fear memory storage.
- T Follicular Helper Cell Differentiation
The transcription factors that regulate follicular T helper cell differentiation are identified.
- Going Retro
The short legs that characterize certain dog breeds are associated with a gene that arose recently by RNA-based gene duplication.
