Contents
Vol 2, Issue 86
Contents
Research Article
- IL-1 Induces IGF-Dependent Epithelial Proliferation in Prostate Development and Reactive Hyperplasia
A classically inflammatory mediator, interleukin-1, also functions during development in the prostate.
Perspective
- Tumor Suppression by LKB1: SIK-ness Prevents Metastasis
Salt-inducible kinase 1 is activated by LKB1 to promote anoikis, thereby blocking metastasis.
Review
- Stress at the Synapse: Signal Transduction Mechanisms of Adrenal Steroids at Neuronal Membranes
Adrenal steroids regulate neuronal excitability by altering ion channel conductance or gene transcription.
Protocol
- Analysis of Signaling Events by Dynamic Phosphoflow Cytometry
State-specific antibodies combined with flow cytometry detect the activity of signaling pathways.
Editors' Choice
- Pass It On
Small RNAs can be transferred between human B cell and T cell lines in a cell contact–dependent manner.
- A Dual-Function Nox Partner
Riboflavin kinase provides a cofactor for NADPH oxidase and recruits it to tumor necrosis factor receptor 1.
- Refining Signaling Domains
Cilia are required for maximal Hedgehog, but not Wnt, signaling in zebrafish.
- Twins Don’t Always Act Alike
TREK1 and TREK2 channels show opposite responses to changes in external pH.
- Regulating Akt
Localization and activation of signaling proteins in cancer cells are controlled by ubiquitin labeling.
- Treg Responses to Eos
A transcription factor required for gene suppression in regulatory T cells is identified.
